NRN1 and CAT Gene Polymorphisms, Complex Noise, and Lifestyles interactively Affect the Risk of Noise-induced Hearing Loss  

作　　者：LIU Shuang Yan SONG Wei Qin XIN Jia Rui LI Zheng LEI Song CHEN Ying Qi ZHAO Tian Yu WANG Hai Yan XU Liang Wen ZHANG Mei Bian HONG Yu YANG Lei 

机构地区：[1]Medical School,Hangzhou Normal University,Hangzhou 310000,Zhejiang,China [2]Ningbo Center for Disease Control and Prevention,Ningbo 315700,Zhejiang,China [3]Central people's hospital of Zhanjiang,Zhanjiang 524000,Zhejiang,China [4]Institute of Occupational Health and Radiation Protection,Zhejiang Provincial Center for Disease Control and Prevention,Hangzhou 310000,Zhejiang,China

出　　处：《Biomedical and Environmental Sciences》2021年第9期705-718,共14页生物医学与环境科学（英文版）

基　　金：supported by Zhejiang Key Research and Development Program of China[No.2015C03039,No.20152013A01];Zhejiang Provincial Program for the Cultivation of High-level Innovative Health Talents,China;Zhejiang Health Innovative Talent Training Project of China;general scientific research project of Zhejiang Science and Technology Department of China[No.Y201941671];Natural Science Foundation of Zhejiang Provincial,China[LY18H260002]。

摘　　要：Objective The effects of interactions between genetic and environmental factors on the noise-induced hearing loss(NIHL)are still unclear.This study aimed to assess interactions among gene polymorphisms,noise metrics,and lifestyles on the risk of NIHL.Methods A case-control study was conducted using 307 patients with NIHL and 307 matched healthy individuals from five manufacturing industries.General demographic data,lifestyle details,and noise exposure levels were recorded.The Kompetitive allele-specific polymerase chain reaction(KASP)was used to analyze the genotypes of 18 SNPs.Results GMDR model demonstrated a relevant interaction between NRN1 rs3805789 and CAT rs7943316(P=0.0107).Subjects with T allele of rs3805789 or T allele of rs7943316 had higher risks of NIHL than those with the SNP pair of rs3805789-CC and rs7943316-AA(P<0.05).There was an interaction among rs3805789,rs7943316,and kurtosis(P=0.0010).Subjects exposed to complex noise and carrying both rs3805789-CT and rs7943316-TT or rs3805789-CT/TT and rs7943316-AA had higher risks of NIHL than those exposed to steady noise and carrying both rs3805789-CC and rs7943316-AA(P<0.05).The best six-locus model involving NRN1 rs3805789,CAT rs7943316,smoking,video volume,physical exercise,and working pressure for the risk of NIHL was found to be the interaction(P=0.0010).An interaction was also found among smoking,video volume,physical exercise,working pressure,and kurtosis(P=0.0107).Conclusion Concurrence of NRN1 and CAT constitutes a genetic risk factor for NIHL.Complex noise exposure significantly increases the risk of NIHL in subjects with a high genetic risk score.Interactions between genes and lifestyles as well as noise metrics and lifestyles affect the risk of NIHL.

关 键 词：Noise-induced hearing loss KURTOSIS CAT NRN1 LIFESTYLE Interaction Generalized multifactor dimensionality reduction 

分 类 号：R764[医药卫生—耳鼻咽喉科]