Synthesis and Crystal Structure of tert-Butyl(((2R,3R,6R)-3-hydroxy-6-(nitromethyl)-3,6-dihydro-2H-pyran-2-yl)methyl)carbonate  

作　　者：FENG Yong-Kui SU Hua-Lan MUKULA OTUKOL Billy Joel ZHANG Xue-Qing YAO Hui HUANG Nian-Yu 冯永奎;苏华兰;MUKULA OTUKOL Billy Joel;张雪晴;姚辉;黄年玉(Hubei Key Laboratory of Natural Products Research and Development,Key Laboratory of Functional Yeast(China National Light Industry),College of Biological and Pharmaceutical Sciences,China Three Gorges University,Tichang,Hubei 443002,China)

机构地区：[1]Hubei Key Laboratory of Natural Products Research and Development,Key Laboratory of Functional Yeast(China National Light Industry),College of Biological and Pharmaceutical Sciences,China Three Gorges University,Tichang,Hubei 443002,China

出　　处：《Chinese Journal of Structural Chemistry》2021年第9期1205-1212,1110,共9页结构化学（英文）

基　　金：the National Natural Science Foundation of China(No.82003621);Youth Talent Development Foundation of China Three Gorges University。

摘　　要：In this paper,aβ-C-pyranogalactoside(Ⅸ)was synthesized from D-galactose through a nine-step reaction with a total yield of 32%under the palladium catalyst,and its structure was characterized by nuclear magnetic resonance(NMR)and high-resolution electrospray ionization mass spectrometry(HR-ESI-MS).The absolute configuration of this pyranogalactoside was confirmed with a Flack parameter of–0.01(6)by X-ray crystallography using a Cu radiation source.Compound(Ⅸ),C_(12)H_(19)NO_(7),crystal data:monoclinic system,space group P2_(1)2_(1)2_(1),a=8.53480(10),b=9.4207(2),c=18.1308(3)A,V=1457.79(4)A^(3),Z=4,F(000)=616,Dc=1.318 g/cm^(3),μ=0.931 mm^(-1),R=0.0294 and wR=0.0752 for 2875 independent reflections(R_(int)=0.0163)and 2857 observed ones(I>2σ(I)).

关 键 词：X-ray diffraction crystal structure absolute configuration β-C-pyranogalactoside α-glucosidase inhibitory activity 

分 类 号：TQ460.1[化学工程—制药化工]