基于中国双生子人群的冠心病遗传-BMI交互作用研究  

Gene-body mass index interaction on coronary heart disease in Chinese adult twins

作　　者：奚玉娥 高文静[1] 吕筠[1] 余灿清[1] 王胜锋[1] 黄涛 孙点剑一 廖春晓[1] 逄增昌[2] 俞敏[3] 汪华[4] 吴先萍[5] 董忠[6] 吴凡[7] 江国虹[8] 王晓节[9] 刘彧 邓健[11] 陆林[12] 曹卫华[1] 李立明[1] Xi Yu'e;Gao Wenjing;Lyu Jun;Yu Canqing;Wang Shengfeng;Huang Tao;Sun Dianjianyi;Liao Chunxiao;Pang Zengchang;Yu Min;Wang Hua;Wu Xianping;Dong Zhong;Wu Fan;Jiang Guohong;Wang Xiaojie;Liu Yu;Deng Jian;Lu Lin;Cao Weihua;Li Liming(Department of Epidemiology and Biostatistics,School of Public Health,Peking University,Beijing 100191,China;Qingdao Municipal Center for Disease Control and Prevention,Qingdao 266033,China;Zhejiang Provincial Center for Disease Control and Prevention,Hangzhou 310051,China;Jiangsu Provincial Center for Disease Control and Prevention,Nanjing 210009,China;Sichuan Center for Disease Control and Prevention,Chengdu 610041,China;Beijing Center for Disease Prevention and Control,Beijing 100013,China;Shanghai Municipal Center for Disease Control and Prevention,Shanghai 200336,China;Tianjin Centers for Disease Control and Prevention,Tianjin 300011,China;Qinghai Center for Diseases Prevention and Control,Xining 810007,China;Heilongjiang Provincial Center for Disease Control and Prevention,Harbin 150030,China;Handan Center for Disease Control and Prevention,Handan 056001,China;Yunnan Center for Disease Control and Prevention,Kunming 650034,China)

机构地区：[1]北京大学公共卫生学院流行病与卫生统计学系,100191 [2]青岛市疾病预防控制中心,266033 [3]浙江省疾病预防控制中心,杭州310051 [4]江苏省疾病预防控制中心,南京210009 [5]四川省疾病预防控制中心,成都610041 [6]北京市疾病预防控制中心,100013 [7]上海市疾病预防控制中心,200336 [8]天津市疾病预防控制中心,300011 [9]青海省疾病预防控制中心,西宁810007 [10]黑龙江省疾病预防控制中心,哈尔滨150030 [11]邯郸市疾病预防控制中心,056001 [12]云南省疾病预防控制中心,昆明650034

出　　处：《中华流行病学杂志》2021年第9期1573-1579,共7页Chinese Journal of Epidemiology

基　　金：国家自然科学基金(81711530051)。

摘　　要：目的分析冠心病患病的遗传-BMI交互作用。方法利用中国双生子登记系统募集的20340对≥25岁的同性别双生子,构建单变量遗传-环境交互作用模型,通过评估BMI对冠心病遗传效应的修饰作用反映冠心病的遗传-BMI交互作用。结果调整年龄后,在男性中发现BMI对冠心病患病受到的遗传效应有负向修饰作用,遗传效应修饰系数(βa)及95%CI为-0.14(-0.22~-0.04),说明log-BMI每增加1个标准差,冠心病的遗传通径系数减小0.14,从而导致冠心病的遗传效应减小。而且低BMI(<24.0 kg/m^(2))男性冠心病患病的遗传度为0.77(0.65~0.86),而高BMI(≥24.0 kg/m^(2))组对应模型中的遗传度为0.56(0.33~0.74)。在女性中未观察到冠心病的遗传-BMI交互作用。结论中国成年男性双生子人群中发现冠心病患病的遗传-BMI交互作用,且遗传因素在低BMI组冠心病患病中发挥更重要的作用。Objective To explore the gene-body mass index(BMI)interaction on coronary heart disease(CHD)in the Chinese adult twins.Methods A total of 20340 same-sex twin pairs registered in the Chinese National Twin Registry(CNTR)were enrolled in this study.Classical twin structure equation model was used to estimate the gene-BMI interaction on CHD.Results After adjusting for age,we found that genetic variance of CHD differed as the function of BMI in male twins,which indicated the presence of a gene-BMI interaction on CHD(P=0.008).The genetic moderating effect(βa)was-0.14(95%CI:-0.22--0.04),indicating that for each logarithmic transformation value of BMI increase,genetic path parameters would decrease by 0.14,which would result in the decrease of genetic variance of CHD.And the heritability of CHD was 0.77(95%CI:0.65-0.86)among the male twins with lower BMI(<24.0 kg/m^(2)),but 0.56(95%CI:0.33-0.74)among the male twins with high BMI(≥24.0 kg/m^(2)).However,there was no evidence suggesting that BMI could moderate genetic variants of CHD in female.Conclusion We found a significant gene-BMI interaction on CHD in the Chinese male adult twins in China,and the heritability of CHD was higher among the twins whose BMI was<24.0 kg/m^(2).

关 键 词：冠心病 体质指数 遗传-环境交互作用 双生子研究 

分 类 号：R541.4[医药卫生—心血管疾病]