母亲围孕期焦虑与子代先天性心脏病关系的病例对照研究  

Association of maternal anxiety with congenital heart disease in offspring based on case-control study

作　　者：景慧 李晶 杜玉娇 腾雨芯 屈鹏飞 张若 杨姣梅 党少农 Jing Hui;Li Jing;Du Yujiao;Teng Yuxin;Qu Pengfei;Zhang Ruo;Yang Jiaomei;Dang Shaonong(Department of Epidemiology and Biostatistics,School of Public Health,Xi'an Jiaotong University Health Science Center,Xi'an 710061,China;Assisted Reproduction Center,Northwest Women's and Children's Hospital,Xi'an Jiaotong University,Xi'an 710003,China)

机构地区：[1]西安交通大学医学部公共卫生学院流行病与卫生统计学系,710061 [2]西安交通大学附属西北妇女儿童医院辅助生殖中心,710003

出　　处：《中华流行病学杂志》2021年第9期1635-1640,共6页Chinese Journal of Epidemiology

基　　金：国家自然科学基金重点项目(81230016);国家重点研发计划(2017YFC0907200,2017YFC0907201)。

摘　　要：目的研究母亲围孕期焦虑与子代先天性心脏病(CHD)的关系。方法数据来源于2014年1月至2016年12月在陕西省开展的CHD相关危险因素病例对照研究,通过焦虑自评表对母亲围孕期焦虑情绪进行评分,新生儿相关信息通过专业医院或机构提供。通过调整混杂因素的logistic回归分析母亲围孕期焦虑对新生儿CHD的影响,并进行亚组分析探索其稳定性。结果共纳入2429例调查对象,病例组773例,对照组1656例,其中病例组中围孕期焦虑者占10.3%,对照组中围孕期焦虑者占7.8%。在控制混杂因素后,母亲围孕期焦虑得分水平与子代患CHD呈正相关(OR=1.04,95%CI:1.01~1.07),母亲围孕期焦虑者子代发生CHD的风险是无焦虑者的1.43倍(OR=1.43,95%CI:1.00~2.05)。结论母亲围孕期焦虑可能增加子代CHD的风险。Objective To explore the association of maternal anxiety with congenital heart disease(CHD)in offspring.Methods A case-control study design was used in this study.The data were collected in Shaanxi province from January 2014 to December 2016.Neonatal information is provided through specialized hospitals or institutions.Logistic regression model with adjustment for confounding factors was established to analyze the association between maternal perinatal anxiety and CHD in offspring.Meanwhile,subgroup analysis was carried out to explore its stability.Results Our study included 2429 subjects,consisting of 773 cases and 1656 controls.Women with anxiety during pregnancy accounted for 10.3%in the case group,while 7.8%in the control group.After adjusting for confounding factors,the level of maternal anxiety during pregnancy was positively correlated with CHD in the offspring(OR=1.04,95%CI:1.01-1.07).The risk of CHD in the offspring of mothers with anxiety during pregnancy was 1.43 times higher than that in those whose mothers had no anxiety(OR=1.43,95%CI:1.00-2.05).Conclusion Maternal anxiety during pregnancy is probably a risk factor for congenital heart disease in offspring.

关 键 词：焦虑 先天性心脏病 围孕期 

分 类 号：R714.5[医药卫生—妇产科学]