丁酸介导下肠道菌群与宿主免疫互作机制的研究进展  

Crosstalk Mechanism between Intestinal Microbes and Host Immunity Mediated by Microbial Metabolites-Butyrate

作　　者：梁开阳 孙志洪[1] 谭支良[2] 刘勇[2] LIANG Kaiyang;SUN Zhihong;TAN Zhiliang;LIU Yong(College of Animal Science and Technology, Southwest University, Chongqing 400700, China;Key Laboratory of Agro-Ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha 410125, China)

机构地区：[1]西南大学动物科学技术学院,重庆400700 [2]中国科学院亚热带农业生态研究所,亚热带农业生态过程重点实验室,长沙410125

出　　处：《畜牧兽医学报》2021年第10期2710-2720,共11页ACTA VETERINARIA ET ZOOTECHNICA SINICA

基　　金：国家自然科学基金(31702141);湖南创新型省份建设专项经费资助(2020NK2012);亚热带农业生态过程重点实验室项目(2020000049)。

摘　　要：肠道菌群或其代谢产物在动物机体生长发育与功能完善方面起重要作用,当宿主与肠道菌群间的动态平衡被打破,可诱发局部或全身性炎症反应。丁酸不仅作为能源物质为机体提供能量,还能调控宿主先天性免疫和适应性免疫状态,促进机体免疫应答;并影响宿主分泌抗菌肽(AMPs)等预防肠道病原菌易位,维持肠道菌群的稳态。本文将系统介绍丁酸介导下肠道菌群与宿主免疫系统间互作机制的研究进展,并阐明其在肠道健康稳态中的重要作用。The intestinal microbes and their metabolites play an important role in the growth and functional improvement of the animal.When the dynamic balance between the host and the intestinal microbes is broken,the local or systemic inflammation is induced.Butyrate not only provides energy for the body as an energy substance,but also regulates the host’s innate immunity and adaptive immune state,promotes the body’s immune response.Butyrate affects the host’s secretion of antimicrobial peptides(AMPs)to prevent translocation of intestinal pathogenic bacteria and maintain steady state of intestinal microbes.This article will systematically introduce the research progress of the interaction mechanism between the intestinal microbes and the host immune system mediated by butyrate,and clarify their important role in the steady state of intestinal health.

关 键 词：肠道菌群 丁酸 宿主免疫 互作机制 

分 类 号：S852.4[农业科学—基础兽医学]