左氧氟沙星与莫西沙星对耐多药肺结核的疗效  

Effect of levofloxacin and moxifloxacin on multidrug-resistant tuberculosis

作　　者：黄玲[1] 刘国辉[1] HUANG Ling;LIU Guohui(Department of Pulmonary,the Third People’s Hospital of Shenzhen,Shenzhen 518000,China)

机构地区：[1]深圳市第三人民医院肺科,深圳518000

出　　处：《上海医药》2021年第19期10-11,18,共3页Shanghai Medical & Pharmaceutical Journal

摘　　要：目的:研究左氧氟沙星与莫西沙星对耐多药肺结核患者痰菌转阴及血清炎症因子的影响。方法:选取180例耐多药肺结核患者,按随机数表法分为对照组和试验组各90例,对照组给予左氧氟沙星治疗,试验组给予莫西沙星治疗。治疗6个月后,比较两组患者的痰菌转阴情况及血清炎症因子水平。结果:试验组治疗有效率及痰菌转阴情况优于对照组,肿瘤坏死因子-α、白介素-6及白介素-1水平低于对照组(P<0.05)。结论:莫西沙星治疗耐多药肺结核的有效率、痰菌转阴率较高,可降低血清炎症因子水平,且不良反应发生率较低。Objective:To study the effects of levofloxacin and moxifloxacin on bacterial negative rate in sputum and serum inflammatory factors in patients with multidrug-resistant tuberculosis.Methods:A total of 180 patients with multi-drug resistant tuberculosis were selected and divided into a control group and a experimental group with 90 cases each based on a random number table method.The control group was treated with levofloxacin while the experimental group with moxifloxacin.The bacterial negative rate in sputum and the levels of serum inflammatory factors were compared between the two groups 6 months after treatment.Results:The effective rates and bacterial negative rate in sputum were better and the levels of tumor necrosis factor-α,interleukin-6 and interleukin-1 were lower in the experimental group than the control group(P<0.05).Conclusion:Moxifloxacin is more effective in the treatment of patients with multi-drug-resistant tuberculosis,has a higher bacterial negative rate in sputum,and can decrease the levels of serum inflammatory factors and the incidence of adverse reactions.

关 键 词：左氧氟沙星 莫西沙星 耐多药肺结核 痰菌转阴 血清炎症因子 

分 类 号：R987.3[医药卫生—药品] R521[医药卫生—药学]