沙美特罗替卡松气雾剂联合粉尘螨滴剂舌下免疫治疗尘螨过敏性哮喘的临床效果  

Clinical effect of salmeterol xinafoate and fluticasone propionate aerosol combined with sublingual immunotherapy with dust mite drops on dust mite allergic asthma

作　　者：郑芳 卞相丽 李妙晨 吴志敏 ZHENG Fang;BIAN Xiang-li;LI Miao-chen;WU Zhi-min(Department of Pediatrics, East Branch of the Sixth People′s Hospital of Shanghai City, Shanghai 200000, China)

机构地区：[1]上海市第六人民医院东院儿科,上海200000

出　　处：《河北医科大学学报》2021年第10期1180-1184,共5页Journal of Hebei Medical University

基　　金：上海市第六人民医院东院院级科研基金项目(院人才2016021)。

摘　　要：目的观察总结尘螨过敏性哮喘患儿接受沙美特罗替卡松气雾剂联合舌下含服粉尘螨滴剂治疗的临床效果。方法选择我院门诊收治的尘螨过敏性哮喘患儿85例为研究对象,依照随机数字表法分为2组,分别接受沙美特罗替卡松气雾剂治疗(对照组42例)与沙美特罗替卡松气雾剂联合粉尘螨滴剂舌下免疫治疗(观察组43例),评价2组患儿治疗效果及治疗前后临床指标变化情况,并统计分析2组患儿治疗期间不良反应发生情况。结果治疗后总有效率比较,观察组总有效率为93.02%(40/43)明显高于对照组的76.19%(32/42),差异有统计学意义(P<0.05);观察组治疗后血清尘螨人特异性免疫球蛋白(specific immunoglobulin,SIg)G4、血清白细胞介素(interleukin,IL)12指标改善均优于对照组,差异有统计学意义(P<0.05);观察组治疗后哮喘日间症状评分、夜间症状评分均低于对照组,比较差异有统计学意义(P<0.05);治疗期间2组患儿均存在轻微程度的咽喉疼痛,其中观察组4例(9.30%)、对照组3例(7.14%),差异无统计学意义(χ2=0.131,P=0.717)。结论尘螨过敏性哮喘患儿行沙美特罗替卡松气雾剂联合粉尘螨滴剂舌下免疫治疗,对患儿气道炎症、免疫失衡等哮喘症状改善效果明显,具有较高的临床应用价值。Objective To observe and summarize the clinical effect of salmeterol xinafoate and fluticasone propionate aerosol combined with sublingual dust mite drops in children with dust mite allergic asthma.Methods A total of 85 children with dust mite allergic asthma who were admitted to our hospital were selected and divided into 2 groups by random number table method.The control group received salmeterol xinafoate and fluticasone propionate aerosol(n=42)and the observation group received salmeterol xinafoate and fluticasone propionate aerosol combined with sublingual immunotherapy with dust mite drops(n=43).The therapeutic effects of the two groups and the changes in clinical indicators before and after treatment were summarized,and incidence of adverse reactions during treatment was analyzed in two groups.Results After treatment,the total effective rate in the observation group was 93.02%(40/43),which was significantly higher than 76.19%(32/42)in the control group,and the difference was statistically significant(P<0.05).After treatment,the improvement of serum dust mite specific immunoglobulin G(SIgG4)and serum interleukin(IL)-12 in the observation group was better than that in the control group,and the difference was statistically significant(P<0.05).The daytime symptom score and nighttime symptom score of asthma in the observation group were lower than those in the control group after treatment,and the difference was statistically significant(P<0.05).During the treatment period,there was mild throat pain in both groups,including 4 cases(9.30%)in the observation group and 3 cases(7.14%)in the control group,however,there was no statistically significant difference(χ2=0.131,P=0.717).Conclusion Salmeterol xinafoate and fluticasone propionate aerosol combined with sublingual immunotherapy with dust mite drops for children with dust mite allergic asthma is effective in ameliorating the asthma symptoms of children such as airway inflammation and immune imbalance.Therefore,it has good application value in clinical practice

关 键 词：哮喘 氟替卡松-沙美特罗替合剂 儿童 

分 类 号：R562.25[医药卫生—呼吸系统]