4-(2-乙氧羰基乙基)苯基硼酸的合成及工艺优化  

Study on the Optimization of Synthesis of 4-(2-Ethoxycarbonyl ethyl)phenylboric Acid

作　　者：刘春江 骆荣双 毛顺艺 黄筑艳[1] LIU Chun-jiang;LUO Rong-shuang;MAO Shun-yi;HUANG Zhu-yan(School of Pharmaceutical Sciences,Guizhou University,Guizhou Engineering Laboratory for Synthetic Drugs,Guiyang 550025,China)

机构地区：[1]贵州大学药学院,贵州省合成药物工程实验室,贵州贵阳550025

出　　处：《广州化学》2021年第4期29-33,共5页Guangzhou Chemistry

摘　　要：以对甲酰基苯硼酸为起始原料,经Wittig-Horne反应、催化氢化2步反应合成了目标化合物,终产物结构经1H-NMR确证。通过单因素实验,分析了每一步反应的关键影响因素,对合成条件进行了优化,反应总收率为77.33%。该方法合成条件简单、原料廉价易得、操作简便且收率较高。The target compound was synthesized from p-formylphenylboric acid by Wittg-Horne reaction and palladium-carbon hydrogenation reduction.Through the single factor experiment,the key factors affecting each step of the reaction were analyzed.The structure of the final product was confirmed by 1 H-NMR.The synthesis condition of this method is simple,the raw material is cheap and easy to obtain,the operation is simple,the cutting yield is high,and the total yield of the reaction is 77.33%.

关 键 词：4-(2-乙氧羰基乙基)苯基硼酸 合成 工艺优化 对甲酰基苯硼酸 Wittig-Horne反应 

分 类 号：O625.11[理学—有机化学] TQ128.54[理学—化学]