不同瑞芬太尼血浆靶浓度对小儿气腹刺激时七氟烷MACBAR的影响  

Effects of different target-controlled concentrations of remifentanil on the MAC_(BAR) of sevoflurane during pneumoperitoneum stimulation in children

作　　者：徐娟[1] 王丹[1] 杨小霖[2] XU Juan;WANG Dan;YANG Xiaolin(Department of Anesthesia,Affiliated Hospital of North Sichuan Medical College,Nanchong,Sichuan 637000,China;The Second Affiliated Hospital of North Sichuan Medical College,Nanchong,Sichuan 637000,China)

机构地区：[1]川北医学院附属医院麻醉科,四川南充637000 [2]川北医学院第二附属医院,四川南充637000

出　　处：《重庆医学》2021年第19期3318-3321,共4页Chongqing medicine

基　　金：四川省医学会科研课题(S15025)。

摘　　要：目的观察小儿行腹腔镜手术时,靶控输注不同浓度瑞芬太尼对气腹刺激时七氟烷抑制肾上腺素能反应的最低肺泡有效浓度(MACBAR)的影响。方法选择拟行腹腔镜疝修补术的3~7岁患儿75例,分为3组,瑞芬太尼靶浓度分别为0 ng/mL(R0组)、1 ng/mL(R1组)及2 ng/mL(R2组)。采用序贯法测定各组七氟烷MACBAR。结果R0、R1及R23组七氟烷MACBAR分别为(3.29±0.17)%、(2.12±0.10)%、(1.29±0.11)%,差异有统计学意义(P<0.05)。结论不同瑞芬太尼血浆靶浓度可不同程度降低小儿腹腔镜手术时七氟烷的MACBAR。Objective To observe the effect of target-controlled infusion of different concentrations of remifentanil on the minimum alveolar concentration of sevoflurane inhabiting adrenergic response(MACBAR)in children undergoing laparoscopic surgery.Methods A total of 75 children aged 3 to 7 years old who would undergo laparoscopic hernia repair were randomly divided into three groups with remifentanil target concentrations of 0 ng/mL(R0 group),1 ng/mL(R1 group)and 2 ng/mL(R2 group),respectively.The MACBAR of sevoflurane in each group was determined by the sequential method.Results The MACBAR of sevoflurane in the R0,R1 and R2 groups were(3.29±0.17)%,(2.12±0.10)%and(1.29±0.11)%,respectively,and the difference was significantly different(P<0.05).Conclusion Different target concentrations of remifentanil can effectively reduce the MACBAR of sevoflurane during laparoscopic surgery in children to varying degree.

关 键 词：瑞芬太尼 七氟烷 小儿 气腹 最低肺泡有效浓度 

分 类 号：R614.2[医药卫生—麻醉学]