四磨汤口服液联合布拉氏酵母菌治疗功能性消化不良患儿的效果及对胃肠激素水平的影响  

Effect of Simo Decoction Oral Liquid and Saccharomyces boulardii in Treating Children with Functional Dyspepsia and Its Influence on Gastrointestinal Hormone Levels

作　　者：赵艳 张海涛 ZHAO Yan;ZHANG Hai-tao(Department of Pediatrics,Suzhou Hospital of Integrated Traditional Chinese and Western Medicine,Suzhou Jiangsu 215101)

机构地区：[1]苏州市中西医结合医院儿科,江苏苏州215101

出　　处：《世界中西医结合杂志》2021年第9期1679-1683,共5页World Journal of Integrated Traditional and Western Medicine

基　　金：江苏省卫生健康委科研课题项目(H2018109)。

摘　　要：目的探讨四磨汤口服液联合布拉氏酵母菌治疗功能性消化不良(Functional dyspepsia,FD)患儿的效果及其对胃肠激素水平的影响。方法选取2019年1月—2020年1月收治的114例FD患儿,应用随机数字表法将患儿分为观察组与治疗组各57例。两组患儿均给予常规基础治疗,对照组采用布拉氏酵母菌治疗,观察组采用四磨汤口服液联合布拉氏酵母菌治疗。对治疗前后中医症状(腹胀、胃脘痛、纳差少食、不易消化)积分、胃肠激素[胃动素(motilin,MTL)、胃泌素(gastrin,GAS)、血管活性肠肽(vasoactive intestinal peptide,VIP)]、胃动力学(胃窦收缩频率、胃窦收缩幅度、胃半排空时间)进行观察,评估治疗效果、统计不良反应及复发率。结果治疗2周后,两组患儿腹胀、胃脘痛、纳差少食、不易消化积分较治疗前降低,差异有统计学意义(P<0.05),与对照组比较,观察组上述积分更低,差异有统计学意义(P<0.05)。治疗2周后,两组患儿MTL、GAS水平较治疗前升高,VIP水平较治疗前降低,差异有统计学意义(P<0.05),观察组MTL、GAS水平高于对照组,VIP水平低于对照组,差异有统计学意义(P<0.05)。治疗2周后,两组患儿胃窦收缩频率、胃窦收缩幅度均较治疗前升高,胃半排空时间较治疗前缩短,差异有统计学意义(P<0.05),观察组胃窦收缩频率及胃窦收缩幅度高于对照组,而胃半排空时间低于对照组,差异有统计学意义(P<0.05)。观察组总有效率96.49%较对照组85.96%更高,差异有统计学意义(P<0.05)。观察组不良反应率12.28%与对照组10.53%相当,差异无统计学意义(P>0.05),观察组复发率为5.45%,低于对照组18.18%,差异有统计学意义(P<0.05)。结论四磨汤口服液联合布拉氏酵母菌治疗FD患儿疗效突出,能改善胃肠激素水平及胃动力学,安全性及预后佳。Objective To investigate the effect of Simotang oral liquid combined with boulardii in the treatment of children with functional dyspepsia(FD)and its influence on the level of gastrointestinal hormones in children.Methods The observation objects were 114 children with FD who admitted in Suzhou hospital of integrated traditional Chinese and western medicine from January 2019 to January 2020.The children were divided into two groups by random number table method.First,the two groups of children were given conventional basic treatment.57 cases in the control group were treated with Saccharomyces boulardii,and 57 cases in the observation group were treated with Simotang oral liquid combined with Saccharomyces boulardii.Before and after treatment,the TCM symptoms(abdominal bloating,abdominal pain,poor appetite,poor digestion),gastrointestinal hormones[motilin(MTL),gastrin(GAS),vasoactive intestinal peptides(VIP)],gastric dynamics(frequency of gastric antrum contraction,gastric antrum contraction amplitude,gastric half emptying time)were observed,the treatment effect was evaluated,and adverse reactions and recurrence rates were counted.Results After 2 weeks of treatment,the scores of abdominal distension,epigastric pain,poor appetite,and indigestibility of the two groups of children were lower than before treatment,and the difference was statistically significant(P<0.05).Compared with the control group,the observation group had lower scores,The difference was statistically significant(P<0.05).After 2 weeks of treatment,the levels of MTL and GAS of the two groups of children were higher than before treatment,and the level of VIP was lower than before treatment.The difference was statistically significant(P<0.05).The level of MTL and GAS ofthe observation group was higher than that of the control group,and the level of VIP was lower.In the control group,the difference was statistically significant(P<0.05).After 2 weeks of treatment,the frequency of gastric antrum contraction and the amplitude of gastric antrum contractio

关 键 词：四磨汤口服液 布拉氏酵母菌 功能性消化不良 胃肠激素 胃动力学 

分 类 号：R259[医药卫生—中西医结合]