骨靶向药物双膦酸盐和地舒单抗治疗实体瘤骨转移的研究进展  

Research progress in bisphosphonates and denosumab therapy for solid tumors with bone metastasis

作　　者：钟红 邓慧远 周义录 孔文强 宋碧辉 ZHONG Hong;DENG Hui-yuan;ZHOU Yi-lu;KONG Wen-qiang;SONG Bi-hui(Department of Pharmacy,Zigong First People’s Hospital,Zigong Sichuan 643000)

机构地区：[1]自贡市第一人民医院药剂科,四川自贡643000

出　　处：《中南药学》2021年第10期2118-2122,共5页Central South Pharmacy

摘　　要：骨靶向药物双膦酸盐和地舒单抗用于实体瘤骨转移,在减少或延缓骨相关事件方面具有良好的临床疗效,但相关药物选择、给药方案、治疗持续时间及如何避免不良反应仍值得探讨。本文将从骨靶向药物的作用机制及其在实体瘤骨转移中的应用进行综述,为临床用药提供参考。Bone-targeted agents,bisphosphonates and denosumab,have shown effective in reducing or delaying skeletal-related events,but such issues as drug selection,dosing schedule,duration of therapy and how to avoid toxicity need more attention.The article aims to review the mechanism of bone-targeted agents and their research progress in the treatment of solid tumors with bone metastasis,and provide reference for clinical medication.

关 键 词：双膦酸盐 地舒单抗 骨转移 骨相关事件 实体瘤 

分 类 号：R96[医药卫生—药理学]