影响妊娠期糖脂代谢的相关因素研究  

Related factors affecting glucose and lipid metabolism during pregnancy

作　　者：曾丹[1] 文芳 王青溪[1] 邱爱珠[1] 欧阳翌国[1] 李菁 ZENG Dan;WEN Fang;WANG Qingxi;QIU Aizhu;OUYANG Yiguo;LI Jing(Hunan Traditional Chinese Medical College,Zhuzhou,Hunan 412012,China;Department of Obstetrics and Gynecology,Cili County Hospital of Traditional Chinese Medicine,Zhangjiajie,Hunan 427200,China)

机构地区：[1]湖南中医药高等专科学校,湖南株洲412012 [2]慈利县中医院妇产科,湖南张家界427200

出　　处：《中国医学工程》2021年第10期66-68,共3页China Medical Engineering

摘　　要：目的探讨妊娠期孕妇影响糖脂代谢的相关因素。方法选取2020年6月至2021年5月慈利县中医院收治的糖脂代谢异常孕妇80例作为观察组。另择取同期该院行孕检且代谢正常的孕妇80例作为对照组。对两组孕妇炎症因子[白细胞介素1(IL-1)、白细胞介素6(IL-6)、白细胞介素8(IL-8)]、糖脂代谢指标[空腹血清胰岛素(FINS)、稳态胰岛素评价指数(HOMA-IR)]、骨骼肌质量指数(SMI)、体重指数(BMI)进行比较,分析炎症因子水平、SMI与糖脂代谢指标的相关性。结果对照组炎症因子较观察组低(P<0.05)。对照组糖脂代谢指标较观察组低(P<0.05)。对照组SMI较观察组高(P<0.05),而BMI较观察组低(P<0.05)。经Pearson分析显示,BMI、SMI与FINS呈正相关关系(r=0.232和0.393,P=0.039和0.043),SMI、IL-6与HOMA-IR呈正相关关系(r=0.481,P=0.021),而IL-6与HOMA-IR呈负相关关系(r=-0.564,P=0.001)。结论炎症因子与糖脂代谢水平间具有明显的相关性,其具备一定的临床价值,提示孕期应当通过合理膳食等进行预防。【Objective】To explore the related factors affecting glucose and lipid metabolism in pregnant women.【Methods】Eighty pregnant women with abnormal glucose and lipid metabolism treated in Cili County Hospital of Traditional Chinese Medicine from June 2020 to May 2021 were selected as the observation group.In addition,80 pregnant women with normal metabolism who underwent pregnancy examination in the hospital in the same period were selected as the control group.The inflammatory factors[interleukin-1(IL-1),interleukin-6(IL-6),interleukin-8(IL-8)],glucose and lipid metabolism indexes[fasting serum insulin(FINS),homeostatic insulin evaluation index(HOMA-IR)],skeletal muscle mass index(SMI)and body mass index(BMI)were compared between the two groups.The correlation between inflammatory factor level,SMI and glucose and lipid metabolism indexes was analyzed.【Results】The inflammatory factors in the control group were lower than those in the observation group(P<0.05).The indexes of glucose and lipid metabolism in the control group were lower than those in the observation group(P<0.05).The SMI of the control group was higher than that of the observation group(P<0.05),and the BMI was lower than that of the observation group(P<0.05).Pearson analysis showed that BMI and SMI were positively correlated with FINS(r=0.232,0.393,P<0.05),SMI and IL-6 were positively correlated with HOMA-IR(r=0.481,P=0.021),and IL-6 was negatively correlated with HOMA-IR(r=-0.564,P=0.001).【Conclusion】There is a significant correlation between inflammatory factors and glucose and lipid metabolism,which has certain clinical value.At the same time,it should also be prevented by reasonable diet during pregnancy.

关 键 词：妊娠期 糖脂代谢 代谢紊乱 影响因素 

分 类 号：R589.1[医药卫生—内分泌]