内皮-间充质转分化在腹膜透析相关腹膜纤维化中的研究进展  

Research advances of endothelial-mesenchymal transition during peritoneal dialysis-related peritoneal fibrosis

作　　者：廖梦 陈思洁 汤日宁[1,3] 张晓良[1] Liao Meng;Chen Si-jie;Tang Ri-ning;Zhang Xiao-liang(Department of Nephrology,Zhongda Hospital,School of Medicine,Southeast University,Nanjing 210009,China;School of Medicine,Southeast University,Nanjing 210009,China;Department of Nephrology,Lishui Branch of Zhongda Hospital,Southeast University,Nanjing 211200,China.)

机构地区：[1]东南大学附属中大医院肾内科,南京210009 [2]东南大学医学院,南京210009 [3]东南大学附属中大医院溧水分院肾内科,南京211200

出　　处：《临床肾脏病杂志》2021年第10期848-855,共8页Journal Of Clinical Nephrology

基　　金：国家自然科学基金(31571186、81770735);江苏省卫计委科教强卫重点医学人才资助(ZDRCA2016079);江苏省卫健委“六个一工程”(LGY2018097)。

摘　　要：腹膜透析是终末期肾脏病患者的肾脏替代治疗之一。腹膜透析相关腹膜纤维化是患者退出腹膜透析最重要的原因。既往研究认为腹膜纤维化的主要机制是上皮-间充质转分化(epithelial-mesenchymal transition,EMT)。近年来,研究发现内皮-间充质转分化(endothelial-mesenchymal transition,EndMT)可能是腹膜纤维化的机制之一,高糖、炎症、氧化应激等均可影响腹膜组织中EndMT的发生发展。因此,本文将综述EndMT在腹膜透析相关腹膜纤维化的研究进展。Peritoneal dialysis is one of renal replacement therapies for patients with end-stage renal disease(ESRD).Peritoneal dialysis-related peritoneal fibrosis is the most important reason for withdrawing peritoneal dialysis in ESRD patients.Previous studies have hinted that a major mechanism of peritoneal fibrosis is epithelial-mesenchymal transition(EMT).Recentstudies have found that endothelial-mesenchymal transition(EndMT)may be one of the mechanisms of peritoneal fibrosis.High glucose,inflammation and oxidative stress affect the occurrence and development of EndMT in peritoneal tissues.This review summarized the latest advances of EndMTduring peritoneal dialysis-related peritoneal fibrosis.

关 键 词：内皮-间充质转分化 腹膜纤维化 腹膜透析 

分 类 号：R692.5[医药卫生—泌尿科学] R572.2[医药卫生—外科学]