Effect of nalbuphine on rocuronium injection pain  

作　　者：Wenfang Huang Jinjin Huang Dongpi Wang Yaoqin Hu Jiangmei Wang Hongfei Lin 

机构地区：[1]Department of Anesthesiology,Zhejiang University School of Medicine Children's Hospital,Hangzhou,China

出　　处：《World Journal of Pediatric Surgery》2021年第3期21-25,共5页世界小儿外科杂志（英文）

摘　　要：Objective Rocuronium-associated intravenous injection pain occurs frequently in children during induction of anesthesia.The aim of this study was to systematically evaluate the benefits of nalbuphine in patients with rocuronium-associated injection pain.Methods Ninety children undergoing tonsillectomy and adenoidectomy in our hospital between October 2019 and September 2020 were randomly divided into the following groups,with 30 patients per group:control group(group C),lidocaine group(group L),and nalbuphine group(group N).Routine 0.1 mg/kg midazolam and 2 mg/kg propofol were injected intravenously.After sedation,children in group C,group L,and group N were administered an intravenous injection of saline,lidocaine(10 mg/mL),or nalbuphine hydrochloride(2 mg/mL),respectively,at a dosage of 0.1 mL/kg.Intravenous injection of rocuronium stock solution(0.6 mg/kg)was administered 2 minutes later.Pain was evaluated using Ambeshs 4-pointscale.The incidence of rocuronium injection pain was compared among the three groups,and postoperative adverse reactions,such as drowsiness,bradycardia,hypotension,and respiratory depression,were evaluated.Results The incidence of injection pain among children in group N was significantly lower than that in group C and group L(p<0.05).The incidence of drowsiness in group N was significantly higher than that in the other groups(p<0.05).The incidences of hypotension,bradycardia,and respiratory depression were not significantly different among the three groups(p>0.05).Conclusions Intravenous nalbuphine during induction of anesthesia effectively prevented rocuronium-associated injection pain in children.Drowsiness is a complication.

关 键 词：INJECTION PAIN DOSAGE 

分 类 号：R614[医药卫生—麻醉学]