肺结核患者呼吸道感染菌群特点及影响因素分析  

Flora characteristics and influencing factors of respiratory tract infection in patients with pulmonary tuberculosis

作　　者：刘丽 张凌林 LIU Li;ZHANG Ling-lin(Department of Infectious Diseases,Rugao People’s Hospital,226500,China)

机构地区：[1]如皋市人民医院感染性疾病科,226500

出　　处：《传染病信息》2021年第5期456-458,共3页Infectious Disease Information

摘　　要：目的对我院肺结核患者呼吸道感染菌群特点进行分析。方法选取我院2017年1月—2019年12月收治的120例肺结核合并呼吸道感染者作为感染组,并选取同期121例肺结核未发生呼吸道感染者作为未感染组。采集感染组患者的痰液进行分离培养鉴定,分析病原学特点。采用单因素和多因素Logistic回归分析研究肺结核患者呼吸道感染影响因素以及干预措施。结果感染组总共分离出143株致病菌,其中革兰阴性菌88株,革兰阳性菌33株,真菌22株。感染组年龄≥70岁、抗菌药物使用种类> 2种、抗菌药物使用时间> 7 d、住院时间> 15 d和初治患者的比例均高于未感染组,差异有统计学意义(P均<0.05)。年龄、住院时间、抗菌药物使用种类、抗菌药物使用时间、初复治情况均为影响肺结核患者呼吸道感染的危险因素(P均<0.05)。结论肺结核患者呼吸道感染主要与年龄、住院时间、抗菌药物使用种类、抗菌药物使用时间、初复治情况等因素有关,病原菌主要是以革兰阴性菌为主。Objective To analyze flora characteristics of respiratory tract infection in patients with pulmonary tuberculosis.Methods One hundred and twenty patients with pulmonary tuberculosis and respiratory tract infection admitted to our hospital from January 2017 to December 2019 were enrolled as infection group, and another 121 patients with pulmonary tuberculosis and without respiratory tract infection were collected as non-infection group. The sputum samples of patients in infection group were collected for separation, culture and identification. The etiological characteristics were analyzed. Univariate and multivariate Logistic regression analysis were used to investigate the influencing factors and intervention measures of respiratory tract infection in patients with pulmonary tuberculosis. Results A total of 143 strains of pathogenic bacteria were isolated in the infection group, including 88 strains of Gram-negative bacteria, 33 strains of Gram-positive bacteria and 22 strains of fungi. The proportion of age ≥ 70 years, types of antibacterial drugs > 2, days of antibiotics use > 7, hospital stay length > 15 days and treatment-na?ve patients in the infection group was significantly higher than that of non-infection group(P <0.05). The age, hospital stay length, types of antibacterial drugs, days of antibiotics use and initial treatment and retreatment results were independent risk factors affecting respiratory tract infection in patients with pulmonary tuberculosis(P <0.05). Conclusions The respiratory tract infection in patients with pulmonary tuberculosis is mainly related to factors such as age, hospital stay length, types of antibacterial drugs, days of antibiotics use, initial treatment and retreatment results. The pathogenic bacteria are dominated by Gram-negative bacteria.

关 键 词：肺结核 呼吸道感染 影响因素 病原学特点 干预措施 

分 类 号：R521[医药卫生—内科学] R56[医药卫生—临床医学]