急性淋巴细胞白血病患儿癌因性疲乏与生存质量的相关性分析  

Correlation between cancer-related fatigue and quality of life in children with acute lymphoblastic leukemia

作　　者：马丽[1] 曲航菲 顾晓明 彭荣 Ma Li;Qu Hangfei;Gu Xiaoming;Peng Rong(Pediatric Ward Blood,Shengjing Hospital of China Medical University,Shenyang 110022,China)

机构地区：[1]中国医科大学附属盛京医院小儿血液病房,沈阳110022

出　　处：《中国医学前沿杂志（电子版）》2021年第10期84-88,共5页Chinese Journal of the Frontiers of Medical Science(Electronic Version)

基　　金：辽宁省自然科学基金指导计划项目(2019-ZD-0741)。

摘　　要：目的分析急性淋巴细胞白血病(acute lymphoblastic leukemia,ALL)患儿癌因性疲乏与生存质量的相关性。方法选取2018年1月至2020年12月于中国医科大学附属盛京医院就诊的68例ALL患儿纳入观察组,选取同期在该院体检的68例健康儿童纳入对照组。比较两组儿童多维疲乏量表(multidimensional fatigue scale,MFS)、儿童生存质量测定量表4.0(the pediatric quality of life inventory measurement models 4.0,PedsQL^(TM) 4.0)总分,采用Pearson相关性分析探讨ALL患儿癌因性疲乏与生存质量的相关性,采用多元线性回归分析探讨影响ALL患儿生存质量的独立危险因素。结果观察组患儿MFS总分、PedsQL^(TM) 4.0总分均显著低于对照组(均P<0.05)。Pearson相关性分析结果表明,MFS的认知疲乏评分与PedsQL^(TM) 4.0的社会、角色维度评分均呈正相关(均P<0.05),睡眠疲乏评分与生理、社会、角色维度评分均呈正相关(均P<0.05),全身疲乏评分与生理、情感、社会、角色维度评分均呈正相关(均P<0.05)。单因素分析结果显示,不同年龄、居住地、家庭人均月收入、父母婚姻状况、临床危险度分级、化疗阶段、电子设备屏幕每天使用时长、MFS总分的ALL患儿PedsQL^(TM) 4.0总分比较差异均有统计学意义(均P<0.05)。多元线性回归分析结果显示,家庭人均月收入<3000元、化疗处于诱导缓解期、MFS总分<50分均是影响ALL患儿生存质量的独立危险因素(均P<0.05)。结论癌因性疲乏是ALL患儿生存质量的独立影响因素,临床上应及时进行个体化干预,以提高患儿生存质量。Objective To investigate the correlation between cancer-related fatigue and quality of life in children with acute lymphoblastic leukemia(ALL).Method Sixty-eight children with ALL admitted in Shengjing Hospital of China Medical University from January 2018 to December 2020 were selected as observation group,and 68 healthy children during the same period in that hospital were randomly selected as control group.The total scores of multidimensional fatigue scale(MFS)and the pediatric quality of life inventory measurement models 4.0(PedsQL^(TM)4.0)were compared between the two groups,Pearson correlation analysis was used to explore the correlation between cancer-related fatigue and quality of life in children with ALL,and multiple linear regression analysis was used to explore the independent risk factors affecting quality of life in children with ALL.Result The total scores of MFS and PedsQL^(TM)4.0 in observation group were significantly lower than those in control group(all P<0.05).Pearson correlation analysis showed that cognitive fatigue score of MFS was positively correlated with social and role dimension scores of PedsQL^(TM)4.0(all P<0.05),sleep fatigue score was positively correlated with physiological,social and role dimension scores(all P<0.05),and whole body fatigue score was positively correlated with physiological,emotional,social and role dimension scores(all P<0.05).Univariate analysis showed that there were statistically significant differences in the PedsQL^(TM)4.0 total scores of ALL children with different ages,places of residence,family per capita monthly income,parents'marital status,clinical risk classification,chemotherapy stage,daily use time of electronic device screens,and MFS total scores(all P<0.05).The results of multiple linear regression analysis showed that the family's per capita monthly income<3000 yuan,chemotherapy remission period,and the total MFS score<50 points were independent risk factors affecting the quality of life of children with ALL(all P<0.05).Conclusion Cancerrelated

关 键 词：急性淋巴细胞白血病 癌因性疲乏 生存质量 相关性 

分 类 号：R473.73[医药卫生—护理学]