白色脂肪米色化的免疫调节  

Immune Modulation of Beige Adipogenesis

作　　者：陈虹 尹悦 孙立君 张炜真[1] CHEN Hong;YIN Yue;SUN Li-Jun;ZHANG Wei-Zhen(Department of Physiology and Pathophysiology,Peking University Health Science Center,Beijing 100191,China)

机构地区：[1]北京大学医学部生理学与病理生理学系,北京100191

出　　处：《生理科学进展》2021年第5期321-327,共7页Progress in Physiological Sciences

基　　金：科技部(2017YFC0908900);国家自然科学基金(81730020,81930015,82070592)资助课题。

摘　　要：诱导白色脂肪组织米色化从而促进能量消耗是预防和治疗肥胖的新策略。近年来,大量研究表明免疫细胞在调节白色脂肪米色化中发挥重要的作用。巨噬细胞、嗜酸性粒细胞、固有淋巴细胞、T细胞等都参与调节米色脂肪的生成。本文概述脂肪组织的分类,介绍诱导白色脂肪米色化的免疫途径,分析免疫细胞与脂肪细胞之间的对话,以此探讨免疫干预作为肥胖防治的潜在方法。Induction of the white adipose tissue beiging in order to promote energy consumption is a novel strategy to reduce the excess energy storage of fat mass.Recent studies have indicated that immune cells such as macrophages,eosinophils,innate lymphoid cells and T cells,are critical for the beiging of white adipose tissue.Here,we introduce the white adipose tissue beiging,review the immune pathways critical for this process and highlight the crosstalk between immune cells and adipocytes.Lastly,we discuss the potential of immune intervention in the treatment of obesity.

关 键 词：米色脂肪细胞 白色脂肪细胞 免疫细胞 肥胖 代谢性炎症 

分 类 号：R339[医药卫生—人体生理学]