中药(复方)药代动力学研究进展  

Research progress on pharmacokinetics of traditional Chinese medicine(compound)

作　　者：傅春燕[1,2,3] 刘永辉 曾立[2] 封芬[2] FU Chunyan;LIU Yonghui;ZENG Li;FENG Fen(The First Affiliated Hospital of Shaoyang University, Shaoyang 422000, China;Southwest Hunan Research Center of Engineering for Development and Utilization of Traditional Chinese Medicine, Shaoyang University, Shaoyang 422000, China;Chemistry and Chemical Engineering, Central South University, Changsha 410083, China;The Second Affiliated Hospital of Shaoyang University, Shaoyang 422000, China)

机构地区：[1]邵阳学院附属第一医院,湖南邵阳422000 [2]邵阳学院湘西南中药开发利用湖南省工程中心,湖南邵阳422000 [3]中南大学化学化工学院,湖南长沙410083 [4]邵阳学院附属第二医院,湖南邵阳422000

出　　处：《邵阳学院学报（自然科学版）》2021年第5期101-108,共8页Journal of Shaoyang University：Natural Science Edition

基　　金：湖南省技术创新引导计划临床医疗技术创新引导项目(2018SK51902)。

摘　　要：从中药(复方)药代动力学的研究特点、多组分药代动力学研究策略及研究难点等方面论述了中药(复方)多组分药代动力学研究进展,并把多组分中药(复方)的化学成分研究、药代动力学研究及代谢组学研究结合起来,从辨证论治、整体原则、由外及内研究中药(复方)治疗疾病的药效物质基础及治疗机制,为新药研发与中药配伍机制研究提供方法,为解决复杂中药(复方)研究过程中的瓶颈问题提供思路和借鉴。The research progress of multi-component pharmacokinetics of traditional Chinese medicine(compound)is reviewed from the aspects of research characteristics,research methods and applications,multi-component pharmacokinetics research strategy and research difficulties.We combined the study of chemical composition,pharmacokinetics and metabonomics of multi-component traditional Chinese medicine(compound)to investigate the material basis and therapeutic mechanism from the aspects of syndrome differentiation,overall principle,as well as outside and inside,so as to provide methods for the research of new drug development and compatibility mechanism of traditional Chinese medicine,and to offer ideas and reference for solving the bottleneck problem in the research process of complex traditional Chinese medicine(compound).

关 键 词：中药 中药复方 药代动力学 多组分 

分 类 号：R969.1[医药卫生—药理学]