老年2型糖尿病的临床治疗分析与前瞻性研究  

Clinical Analysis and Prospective Study of Elderly Type 2 Diabetes

作　　者：邵华 荣阳 荣根满 SHAO Hua;RONG Yang;RONG Genman(Department of Endocrinology,Second People's Hospital of Liaoyang City,Liaoyang 111000,China;Medical Service of Liaoyang Central Hospital,Liaoyang 111000,China;Medical Section,Central Hospital of China Railway 19th Bureau Group,Liaoyang 111000,China)

机构地区：[1]辽宁省辽阳市第二人民医院内分泌科,辽宁辽阳111000 [2]辽宁省辽阳市中心医院医务处,辽宁辽阳111000 [3]中铁十九局集团中心医院医务科,辽宁辽阳111000

出　　处：《中国医药指南》2021年第27期108-109,共2页Guide of China Medicine

摘　　要：目的研究分析常规剂量、短疗程辛伐他汀对老年2型糖尿病(T2DM)患者血脂、C反应蛋白(CRP)的影响与临床意义。方法120例LDL-C≥2.6 mmol/L的老年T2DM患者随机分为两组:辛伐他汀组采用辛伐他汀20 mg/d+常规治疗,对照组采用常规治疗。于治疗前及治疗后2周分别测定血脂、超敏C反应蛋白(hs-CRP)等指标。结果治疗2周后,辛伐他汀组TC、TG、LDL-C、hs-CRP较治疗前显著下降,差异具有统计学意义(P<0.05),且hs-CRP下降与TC、TG、LDL-C下降无相关性。对照组的上述指标较治疗前虽有下降,但差异无统计学意义。结论常规剂量、短疗程辛伐他汀可显著降低老年T2DM患者LDL-C水平,而且具有独立于降脂作用之外的显著降低hs-CRP水平的作用,从而具有防治老年T2DM患者动脉粥样硬化的发生、发展的作用,且安全性良好。Objective To study the effect and clinical significance of conventional dose and short-course simvastatin on serum lipids and C-reactive protein(CRP)in elderly patients with type 2 diabetes mellitus(T2DM).Methods One hundred and twenty elderly T2DM patients with LDL-C≥2.6 mmol/L were randomly divided into two groups:the simvastatin group received simvastatin 20 mg/d+conventional treatment,and the control group received conventional treatment.Before treatment and 2 weeks after treatment,blood lipids,high-sensitivity C-reactive protein(hs-CRP)and other indicators were measured.Results After 2 weeks of treatment,TC,TG,LDL-C,and hs-CRP in the simvastatin group were significantly lower than before treatment,the difference was statistically significant(P<0.05),and the decrease in hs-CRP was similar to that of TC,TG,LDL-C there is no correlation between declines.The above indicators in the control group decreased compared with before treatment,but the difference was not statistically significant.Conclusion Conventional dose and short course of simvastatin can significantly reduce the level of LDL-C in elderly T2DM patients,and can significantly reduce the level of hs-CRP independent of lipid-lowering effect,so it can prevent and treat the occurrence and development of atherosclerosis in elderly T2DM patients,and has good safety.

关 键 词：老年2型糖尿病 辛伐他汀 血脂 超敏C反应蛋白 动脉粥样硬化 疗效分析 

分 类 号：R587.1[医药卫生—内分泌]