慢性乙型肝炎肝纤维化的无创诊断模型  

Noninvasive diagnostic models for chronic hepatitis B liver fibrosis

作　　者：杨琴 刘怀鄂[1] 游晶[1] 丁洁 陈丹阳 YANG Qin;LIU Huaie;YOU Jing;DING Jie;CHEN Danyang(Department of Infectious Diseases,The First Affiliated Hospital of Kunming Medical University,Kunming 650032,China;Department of Hepatology,The Third People’s Hospital of Kunming,Kunming 650032,China)

机构地区：[1]昆明医科大学第一附属医院感染科,昆明650032 [2]昆明市第三人民医院肝病综合科,昆明650032

出　　处：《临床肝胆病杂志》2021年第10期2420-2424,共5页Journal of Clinical Hepatology

基　　金：云南省高层次卫生技术人员-后备人才(H-2017071);云南省教育厅科学研究基金项目(2021J0239)。

摘　　要：HBV感染仍然是危及人类生命健康的重大社会公共问题。通过选择高效的无创模型判断慢性HBV感染者肝纤维化进展情况,对于评估病情、病程管理和预后判断具有重要意义。回顾了近年来在肝纤维化诊断领域常用、高效的几类复合模型,归纳了模型的研究背景、使用方法、主要的相关研究,总结了这些研究模型的优缺点,并分析了肝纤维化评估模型的整体研究情况及可能的发展趋势。通过汇总近年来的相关研究表明,尽管当前的研究模型对于我国主要以慢性HBV感染为肝纤维化诱因的患者来说还不完美,但无创模型诊断技术在肝纤维化评估中的优异表现能够为慢性HBV感染者肝纤维化评估提供借鉴和指导,并一定程度的替代肝穿刺检查。Hepatitis B virus(HBV)infection is still a public problem that seriously threatens human health.Evaluation of liver fibrosis progression with an efficient noninvasive model is of great significance for condition assessment,disease management,and prognostic evaluation in patients with chronic HBV infection.This article reviews the noninvasive models commonly used in the diagnosis of liver fibrosis in recent years,summarizes the research background,methods,related studies,and advantages and disadvantages of these models,and analyzes the current research status and possible development trends of liver fibrosis assessment models.Recent studies have shown that although current models are not perfect for Chinese patients with chronic HBV infection as the main predisposing factor for liver fibrosis,the excellent performance of noninvasive models in liver fibrosis assessment provides a reference for the assessment of liver fibrosis in patients with chronic HBV infection and can replace liver biopsy to a certain extent.

关 键 词：乙型肝炎 慢性 肝硬化 诊断 

分 类 号：R512.62[医药卫生—内科学] R575.2[医药卫生—临床医学]