Recent advances in cardiovascular stent for treatment of in-stent restenosis:Mechanisms and strategies  

作　　者：Hang Yao Yuwei He Jinrong Ma Lang Jiang Jingan Li Jin Wang Nan Huang 

机构地区：[1]Key Laboratory of Advanced Technology for Materials of the Education Ministry,School of Materials Science and Engineering,Southwest Jiaotong University,Chengdu 610031,China [2]Department of Chemical Engineering,University of Washington,Seattle 98195,USA [3]Department of Pharmaceutics,School of Pharmacy,Fudan University&Key Laboratory of Smart Drug Delivery,Ministry of Education,Shanghai 201203,China [4]School of Materials Science and Engineering,Zhengzhou University,Zhengzhou 450000,China

出　　处：《Chinese Journal of Chemical Engineering》2021年第9期12-29,共18页中国化学工程学报（英文版）

基　　金：financial support from the National Key Research and Development Program of China(2017YFB0702500);Natural Science Foundation of China(NSFC Project,81801853);Sichuan Science and Technology Program(19GJHZ0058)。

摘　　要：Treatments of atherogenesis,one of the most common cardiovascular diseases(CVD),are continuously being made thanks to innovation and an increasingly in-depth knowledge of percutaneous transluminal coronary angioplasty(PTCA),the most revolutionary medical procedure used for vascular restoration.Combined with an expanding balloon,vascular stents used at stricture sites enable the long-time restoration of vascular permeability.However,complication after stenting,in-stent restenosis(ISR),hinders the advancement of vascular stents and are associated with high medical costs for patients for decades years.Thus,the development of a high biocompatibility stent with improved safety and efficiency is urgently needed.This review provides an overview of current advances and potential technologies for the modification of stents for better treatment and prevention of ISR.In particular,the mechanisms of in-stent restenosis are investigated and summarized with the aim to comprehensively understanding the pathogenesis of stent complications.Then,according to different therapeutic functions,the current stent modification strategies are reviewed,including polymeric drug eluting stents,biological friendly stents,prohealing stents,and gene stents.Finally,the review provides an outlook of the challenges in the design of stents with optimal properties.Therefore,this review is a valuable and practical guideline for the development of cardiovascular stents.

关 键 词：Cardiovascular stent modification In-stent restenosis Late stent thrombosis RE-ENDOTHELIALIZATION Inflammatory modulation 

分 类 号：R54[医药卫生—心血管疾病]