老年人群睡眠时间异常与轻度肾功能降低的关联研究  

Association between sleep length and mild renal function impairment in elderly population

作　　者：石建明[1] 章月蟾 张辉 李淑娟[3] 王笑峰 蒋晓燕[4] SHI Jian-ming;ZHANG Yue-chan;ZHANG Hui;LI Shu-juan;WANG Xiao-feng;JIANG Xiao-yan(Longevity Institute,Rugao People's Hospital,Rugao 226500,Jiangsu Province,China;Human Phenome Institute,Fudan University,Shanghai 200082,China;Dept.of Neurology,Beijing Chaoyang Hospital,Capital Medical University,Beijing 100020,China;School of Medicine,Tongji University,Shanghai 200433,China)

机构地区：[1]如皋市人民医院长寿研究所,江苏如皋226500 [2]复旦大学人类表型组研究院,上海200082 [3]首都医科大学附属北京朝阳医院神经内科,北京100020 [4]同济大学医学院,上海200433

出　　处：《同济大学学报（医学版）》2021年第5期658-663,共6页Journal of Tongji University(Medical Science)

基　　金：国家重点研发计划“主动健康和老龄化科技应对”专项(2018YFC2000400、2018YFC2002000)。

摘　　要：目的探讨老年社区人群中睡眠时间和肾功能降低的关系。方法使用如皋衰老队列1637例70~84岁基线调查数据。肾功能用以肌酐为基础的肾小球滤过率(eGFR)评估。轻度肾功能降低定义为60 mL/(min·1.73 m^(2))≤eGFR<90 mL/(min·1.73 m^(2))。短睡眠时间和长睡眠时间分别定义为睡眠≤6 h/夜和≥9 h/夜。采用Logistic回归分析睡眠时间和eGFR降低间的关联。结果老年男性有57.0%、老年女性有51.9%个体轻度肾功能降低。老年男性平均睡眠(6.80±1.87)h,女性(6.12±1.98)h。老年男性eGFR降低组较eGFR正常组睡眠时间更短[(6.70±1.93)vs(6.92±1.78)h/夜,P=0.027]。老年男性睡眠时间延长与eGFR降低不相关,而睡眠时间不足(≤6 h/夜)与eGFR降低的风险增加相关(OR=1.47,95%CI:1.06~2.04,P=0.021)。多因素校正后显著性依然存在。老年女性睡眠不足与延长均与eGFR降低不相关。结论睡眠时间不足与老年男性轻度肾功能降低风险增加相关。保持充足的睡眠对维持老年男性正常肾功能较重要。Objective To explore the relationship between sleep length and mild renal impairment in community-dwelling elderly.Methods Baseline data of 1637 participants aged 70-84 in the Rugao aging cohort were collected.Kidney function was defined using creatine based estimated glomerular filtration rate(eGFR).Mild renal impairment was defined as 60 mL/(min·1.73 m^(2))≤eGFR<90 mL/(min·1.73 m^(2));short sleep length and long sleep length were defined as≤6 h/night and≥9 h/night,respectively.The relationship between sleep length and eGFR decrease was analyzed with Logistic regression analysis.Results There were 57.0%of the male and 51.9%of the female with mild renal decrease.The average sleep length was(6.80±1.87)h in men and(6.12±1.98)h in women.The sleep length of males with decreased eGFR was shorter than that of males with normal eGFR[(6.70±1.93)h/night vs(6.92±1.78)h/night,P=0.027].There was no significant association between prolonged sleep length and decreased eGFR in males,while insufficient sleep duration(≤6 h/night)was associated with elevated risk of eGFR decrease(OR=1.47,95%CI:1.06-2.04,P=0.021).However,there was no significant association between eGFR and sleep length in females.Conclusion Sleep deprivation is associated with an increased risk of mild renal dysfunction in men,suggesting that it is important to keep enough sleep to maintain normal renal function for elderly men.

关 键 词：睡眠时间异常 肾功能降低 风险因素 老年人群 性别 

分 类 号：R692[医药卫生—泌尿科学]