血脂水平和遗传因素与男性肿瘤发病风险关联  

Association of blood lipid and genetic factor with cancer risk in men

作　　者：胡北平 汪天培 朱猛 颜财旺 靳光付 HU Bei-ping;WANG Tian-pei;ZHU Meng;YAN Cai-wang;JIN Guang-fu(Department of Epidemiology,School of Public Health,Nanjing Medical University,Nanjing 211166,China)

机构地区：[1]南京医科大学公共卫生学院流行病学系,南京211166

出　　处：《中华疾病控制杂志》2021年第9期1003-1007,共5页Chinese Journal of Disease Control & Prevention

基　　金：国家自然科学基金(81872702,82003534);江苏省自然科学基金(BK20200674)。

摘　　要：目的探究血脂水平与遗传因素在男性肿瘤发生中的作用。方法参照既往研究发表的肿瘤多基因风险评分,将英国生物样本库(UK Biobank,UKB)中的男性参与者根据遗传风险分为低、中及高三组;同时又以异常血脂指标数量作为标准,把研究对象分为三个类别,进而探究不同遗传风险下血脂水平与肿瘤发病风险的关联。结果研究共纳入178171名男性作为研究对象,其中11824人(6.64%)在随访期间新发肿瘤。在调整年龄、吸烟、饮酒以及空腹血糖等混杂因素后,血脂异常评分与肿瘤发病风险相关(均有P<0.001)。高遗传风险、高血脂异常评分人群的肿瘤发病风险是低遗传风险、低血脂异常评分人群的2.290倍(95%CI:2.039~2.571,P<0.001)。结论在不同遗传风险人群中,血脂水平异常均可增加男性肿瘤发病风险。Objective To investigate the potential roles of blood lipid levels and genetic factors in cancer development in men.Methods Male participants in the UK Biobank(UKB)were stratified into low,intermediate and high genetic risk groups.The number of abnormal lipid levels was used to divide study subjects into three categories.The association between abnormal levels of blood lipid and the risk of cancer incidence under different genetic risks were analyzed.Results A total of 178171 men were included in the study,of whom 11824(6.64%)developed new cancer cases within the follow-up period.After adjustment for confounders including age,smoking,alcohol consumption,and fasting plasma glucose,abnormal lipid score was associated with the risk of cancer(all P<0.001).Men with high genetic risk and high lipid abnormal score had 2.290 fold higher(95%CI:2.039-2.571,P<0.001)overall cancer risk than those with low genetic risk and low lipid abnormal score.Conclusion Abnormal levels of blood lipid may increase the risk of cancer across different genetic risk groups in men.

关 键 词：血脂 多基因风险评分 肿瘤风险 关联 

分 类 号：R181.2[医药卫生—流行病学] R730.2[医药卫生—公共卫生与预防医学]