血液中的生长分化因子11在抗衰老领域的研究进展  

Advances in the anti-ageing effects of GDF11 in blood

作　　者：王宗奎[1,2] 张容 李长清[1,2] WANG Zongkui;ZHANG Rong;LI Changqing(Institute of Blood Transfusion,Chinese Academy of Medical Sciences&Peking Union Medical College,Chengdu 610052,China;International Science and Technology Cooperation Base of Sichuan Blood Safety and Blood Substitute)

机构地区：[1]中国医学科学院&北京协和医学院输血研究所,四川成都610052 [2]四川省血液安全与血液替代国际科技合作基地

出　　处：《中国输血杂志》2021年第9期1041-1046,共6页Chinese Journal of Blood Transfusion

基　　金：四川省国际科技创新合作项目(2019YFH0018)。

摘　　要：生长分化因子11(GDF11)是转化生长因子β(TGF-β)超家族的一员,在人、小鼠、大鼠、马、羊等多个物种中广泛表达,具有多重生物学功能,在胚胎发育中的前/后轴模式、修复骨骼肌、骨骼形成、血管及神经新生等方面起着重要作用。近年来的研究发现,人血液中的GDF11可以逆转年龄相关的心肌肥大、骨骼肌功能障碍、认知功能减退等,提示GDF11在抗衰老领域有潜在应用价值。然而,也有一些专家质疑GDF11在抗衰老中的作用。本文系统介绍GDF11的结构特征、其在抗衰老领域的研究进展及目前存在的一些争议等,为今后GDF11在抗衰老中的研究工作提供思路。Growth differentiation factor 11(GDF11), a member of the transforming growth factor β superfamily, is widely expressed in multiple species such as human, mouse, rat, horse and sheep. Moreover, GDF11 is implicated in diverse biological functions and plays an important role in regulating anterior/posterior patterning, skeletal muscle regeneration, bone formation, vascular remodeling and neurogenesis. Recent studies have revealed that GDF11 in blood reverses age-related cardiac hypertrophy, skeletal muscle dysfunction and age-related cognitive decline, suggesting the potential value of GDF11 on anti-ageing. However, some other studies questioned the effects of GDF11 on anti-ageing. Herein, we highlighted structural characteristics of GDF11, advances in effects of GDF11 on anti-ageing, and the controversies of GDF11, to provide new insights for future studies on anti-ageing.

关 键 词：生长分化因子11 抗衰老 心肌肥大 骨骼肌 认知功能减退 

分 类 号：R592[医药卫生—老年医学] R459.9[医药卫生—内科学]