血尿酸水平测定用于原发性高血压的临床诊断价值及与病情相关性分析  

The Value of Blood Uric Acid Level in the Clinical Diagnosis of Essential Hypertension and the Analysis of its Correlation with the Disease

作　　者：许馨 徐天祥 XU Xin;XU Tianxiang(Department of Laboratory Medicine,Jurong Branch of Jiangsu Provincial People's Hospital(Jurong City People's Hospital),Jurong,Jiangsu Province,212400 China)

机构地区：[1]江苏省人民医院句容分院(句容市人民医院)检验科,江苏句容212400

出　　处：《世界复合医学》2021年第8期5-8,共4页World Journal of Complex Medicine

基　　金：2019年度句容市民生科技计划项目(SF2019791499)。

摘　　要：目的探讨血尿酸水平测定用于原发性高血压的临床诊断价值,并分析血尿酸水平与病情严重程度的相关性。方法选取该院2018年1月—2020年12月期间经该院确诊的原发性高血压患者82例作为观察对象,测量血压并分1级高血压组、2级高血压组和3级高血压组,并选取同期在该院体检的健康人30名作为健康对照组。比较各组血尿酸水平及高尿酸血症患病率,并对血尿酸水平与高血压病情进行Pearson相关性分析。结果1级高血压组、2级高血压组、3级高血压组血尿酸水平明显较对照组高,差异有统计学意义(t=6.327、8.387、12.223,P<0.05);且2级高血压组和3级高血压组血尿酸水平较1级高血压组高,差异有统计学意义(t=2.179、4.337,P<0.05);3级高血压组血尿酸水平较2级高血压组高,差异有统计学意义(t=2.167,P=0.034)。1级高血压组、2级高血压组、3级高血压组高尿酸血症患病率明显较对照组高,差异有统计学意义(χ^(2)=4.684、4.965、20.399,P<0.05);且3级高血压组高尿酸血症患病率为56.25%,明显高于1级高血压组和2级高血压组,差异有统计学意义(χ^(2)=3.920、5.111,P=0.048、0.024)。经Pearson相关性分析,高血压患者收缩压、舒张压水平与血尿酸水平均存在一定正相关性(r=0.507、0.498,P<0.05)。结论原发性高血压患者多伴血尿酸水平升高,且血尿酸水平与收缩压及舒张压存在一定正相关性,故原发性高血压患者血尿酸水平的升高可能提示高血压病情趋于严重,故临床应重视原发性高血压患者血尿酸水平,及早干预。Objective To explore the clinical diagnostic value of blood uric acid level measurement for essential hypertension,and to analyze the correlation between blood uric acid level and the severity of the disease.Methods A total of 82 patients with primary hypertension diagnosed in the hospital from January 2018 to December 2020 were selected as observation objects.The blood pressure was measured and divided into grade 1 hypertension group,grade 2 hypertension group and grade 3 hypertension group.In the blood pressure group,30 healthy people who had a physical examination in the hospital during the same period were selected as the healthy control group.The blood uric acid level and the prevalence of hyperuricemia in each group were compared,and the Pearson correlation analysis was carried out on the blood uric acid level and the condition of hypertension.Results The blood uric acid levels in the grade 1 hypertension group,grade 2 hypertension group,and grade 3 hypertension group were significantly higher than those in the control group,the difference was statistically significant(t=6.327,8.387,12.223,P<0.05);and the blood uric acid levels of the 2nd and 3rd hypertension groups were higher than those of the 1st hypertension group,the difference was statistically significant(t=2.179,4.337,P<0.05);The level of blood uric acid in the grade 3 hypertension group was higher than that in the grade 2 hypertension group,the difference was statistically significant(t=2.167,P=0.034).The prevalence of hyperuricemia in the grade 1 hypertension group,grade 2 hypertension group,and grade 3 hypertension group was significantly higher than that of the control group,the difference was statistically significant(χ^(2)=4.684,4.965,20.399,P<0.05);and the prevalence of hyperuricemia in the grade 3 hypertension group was 56.25%,which was significantly higher than that of the grade 1 hypertension group and the grade 2 hypertension group,the difference was statistically significant(χ^(2)=3.920,5.111,P=0.048,0.024).According to Pearson correla

关 键 词：原发性高血压 血尿酸水平 临床诊断 病情 相关性 

分 类 号：R544.11[医药卫生—心血管疾病] R743.3[医药卫生—内科学]