GnSAF、LEP和APN在多囊卵巢综合征患者血清中的表达及其意义  

Expression Levels and Significance of GnSAF,LEP and APN in Peripheral Blood of Polycystic Ovarian Syndrome

作　　者：张萍 王坤 ZHANG Ping;WANG Kun(Department of Endocrinology,Peng lai Peoples Hospital,Yantai Shandong 265600 China)

机构地区：[1]山东烟台市蓬莱人民医院内分泌科,山东烟台265600 [2]山东烟台市蓬莱人民医院重症医学科,山东烟台265600

出　　处：《医学临床研究》2021年第9期1338-1341,共4页Journal of Clinical Research

摘　　要：【目的】探讨促性腺激素峰抑制因子(GnSAF)、瘦素(LEP)和脂联素(APN)在多囊卵巢综合征(PCOS)患者血清中的表达及其意义。【方法】选取2017年1月至2019年6月在本院诊治的121例PCOS患者(观察组)及同期因输卵管因素、男方因素或免疫因素等导致不孕不育的非PCOS患者60例(对照组)为研究对象。收集其临床资料,比较两组患者血清GnSAF、LEP、APN水平、促排卵情况及妊娠结局。根据其随访后的妊娠结局将观察组患者分为妊娠成功组及妊娠失败组2个亚组,比较不同妊娠结局患者血清GnSAF、LEP、APN水平。采用受试者工作曲线(ROC)评估血清GnSAF、LEP、APN水平单独及联合检测对PCOS患者及非PCOS不孕症患者的鉴别诊断价值及对PCOS患者妊娠结局的预测价值。【结果】观察组促黄体生成素(LH)、睾酮(T)、空腹胰岛素(FINS)、胰岛素抵抗指数(HOMA-IR)、体重指数(BMI)、GnSAF、LEP水平明显高于对照组(P<0.05),APN水平、排卵率、临床妊娠率明显低于对照组(P<0.05),但两组促卵泡生长激素(FSH)、空腹血糖(FPG)、腰臀比(WHR)、流产率及多胎率比较差异无统计学意义(P>0.05)。ROC曲线结果显示:单独检测及联合检测血清GnSAF、LEP、APN水平均可作为PCOS患者及非PCOS不孕症患者的鉴别诊断指标及预测PCOS患者妊娠结局的效能指标(均P<0.05)。妊娠成功组患者血清GnSAF、LEP水平显著低于妊娠失败组(P<0.05),APN水平显著高于妊娠失败组(P<0.05)。【结论】血清GnSAF、LEP和APN可能参与PCOS的发病及进展,可作为临床早期鉴别不孕原因及预测患者妊娠结局诊断的重要指标,具有一定的临床意义。【Objective】To explore the expression levels and significance of gonadotropin surge-attenuating factor(GnSAF),leptin(LEP)and adiponectin(APN)in the peripheral blood of polycystic ovarian syndrome(PCOS).【Methods】A total of 121 patients with PCOS who were treated in our hospital from January 2017 to June 2019(the observation group)and 60 female patients with non-PCOS infertility diagnosed due to fallopian tube factor,male factor or immune factor during the same time period(the control group)were selected as the study subjects.The clinical data were collected,and the levels of peripheral blood GnSAF,LEP and APN,o-vulation induction and pregnancy outcomes were compared between the two groups.According to the pregnancy outcomes after follow-up,the patients in the observation group were divided into the pregnancy success subgroup and pregnancy failure subgroup.The levels of peripheral blood GnSAF,LEP and APN were compared between different pregnancy outcome subgroups.The receiver operating characteristic(ROC)curve was used to evaluate the differential diagnostic value(alone and combination)of peripheral blood GnSAF,LEP and APN for patients with PCOS and with non-PCOS infertility and predict the pregnancy outcomes of patients with PCOS.【Results】The levels of luteinizing hormone(LH),testosterone(T),fasting insulin(FINS),homeostasis model assessment of insulin resistance(HOMA-IR),body mass index(BMI),GnSAF and LEP in observation group were significantly higher than those in control group(P<0.05),while the APN level,o-vulation rate and clinical pregnancy rate were significantly lower than those in control group(P<0.05).However,there were no statistically significant differences in the follicle stimulating hormone(FSH),fasting blood glucose(FPG),waist-hip ratio(WHR),miscarriage rate and multiple birth rate between the two groups(P>0.05).ROC curve showed that the single detection and combined detection of levels of peripheral blood GnSAF,LEP and APN could be used as differential efficacy indexes for patients with

关 键 词：多囊卵巢综合征 脂联素/血液 瘦素/血液 

分 类 号：R711.75[医药卫生—妇产科学]