妊娠相关蛋白-A、血管内皮生长因子在胚胎停育患者蜕膜组织中的表达及其与子宫动脉血流参数的相关性分析  

Study on the Expression of Pregnancy-associated Protein-A and Vascular Endothelial Growth Factor in Decidual Tissues of Embryonic Cessation and Their Relationship with Ultrasound Blood Flow Parameters of Uterus

作　　者：王晓梅 WANG Xiao-mei(Department of Obstetrics and Gynecology,Suzhou Hospital of Traditional Chinese Medicine,Suzhou Anhui 234000)

机构地区：[1]宿州市中医医院妇产科,安徽宿州234000

出　　处：《医学临床研究》2021年第9期1346-1348,1352,共4页Journal of Clinical Research

摘　　要：【目的】探讨妊娠相关蛋白-A(PAPP-A)、血管内皮生长因子(VEGF)在胚胎停育患者蜕膜组织中的表达及其与子宫动脉血流参数的相关性。【方法】选择2017年11月至2021年2月在本院进行清宫治疗的195例胚胎停育孕妇(观察组)和同期因个人原因进行人工流产的早期正常孕妇180例(对照组)。分别获取两组孕妇的蜕膜组织并检测蜕膜组织中PAPP-A、VEGF的表达水平,同时收集两组孕妇子宫动脉的血流参数[搏动指数(PI)、阻力指数(RI)、收缩期最大血流速度与舒张末期血流速度比值(S/D)]并比较,分析胚胎停育患者蜕膜组织中PAPP-A与VEGF的相关性及两者与子宫动脉血流参数的相关性。【结果】观察组蜕膜组织中PAPP-A、VEGF水平明显低于对照组(P<0.05);观察组优势侧、非优势侧子宫动脉血流参数RI、PI、S/D均明显高于对照组(P<0.05)。相关性分析结果显示:胚胎停育患者蜕膜组织中PAPP-A水平与VEGF水平呈正相关(r=0.824,P<0.05);胚胎停育患者蜕膜组织中PAPP-A、VEGF与子宫动脉血流参数RI、PI、S/D均呈负相关(P<0.05)。【结论】胚胎停育患者蜕膜组织中PAPP-A、VEGF可能通过控制血管新生而改变子宫血流动力学,参与胚胎停育的发展。【Objective】To investigate the expression of pregnancy-associated protein-A(PAPP-A)and vascular endothelial growth factor(VEGF)in the decidual tissues of embryonic cessation and explore their correlation with ultrasound blood flow parameters.【Methods】A total of 195 embryos,who were discontinued from the family planning clinic from November 2017 to February 2021 in the hospital and treated with abortion,were selected as the observation group.During the same period,180 normal pregnant women who had induced abortion due to personal reasons were selected as the control group.Obtain the stripped decidual tissues of the two groups of pregnant women and measure the expression levels of PAPP-A and VEGF in the stripped tissues.Simultaneously,the uterine ultrasound blood flow parameters in the two groups of pregnant women were measured,including the pulsation index(PI),resistance index(RI),and systole.Ratio of maximum blood flow velocity to end-diastolic blood flow velocity(S/D).The expression levels of PAPP-A and VEGF in the two groups of decidual tissues and the changes in the parameters of uterine ultrasound blood flow in the two groups were compared And the correlation in between were analyzed.【Results】The expression levels of PAPP-A and VEGF proteins in the decidual tissue of the obser vation group were significantly lower than those of the control group(P<0.05).The uterine ultrasound blood flow parameters RI,PI,and S/D on the dominant and non-dominant sides in the observation group were significantly higher than those in the control group(P<0.05).Pearson correlation analysis showed that PAPP-A was positively correlated with VEGF expression level in the decidual tissues of patients with embryonic termination(r=0.824,P<0.05).It also showed that both PAPP-A and VEGF were negatively correlated with uterine ultrasound blood flow parameters RI,PI,and S/D(P<0.05).【Conclusion】PAPP-A and VEGF in the decidual tissues of embryonic cessation patients can change the uterine hemodynamics and control the development

关 键 词：胎儿疾病 妊娠相关血浆蛋白A/分析 血管内皮生长因子A/分析 蜕膜/病理生理学 子宫/血液供给 

分 类 号：R169.421[医药卫生—公共卫生与预防医学]