Network pharmacology-based analysis on three amicoumacin-type isocoumarin compounds from an endophytic bacterium in Houttuynia cordata  

作　　者：Yiyao Lu Yinjie Xiong Mengyue Zhang Yingying Wu Jingjing Xu Linyu Zhang Xin Wu 

机构地区：[1]School of life science and biopharmaceutics,Shenyang Pharmaceutical University,Shenyang 110016,China

出　　处：《Asian Journal of Traditional Medicines》2021年第5期255-268,共14页亚洲传统医药（英文）

基　　金：Natural Science Foundation of Liaoning(2019-ZD-0457);Foundation of Career Development Plan for young and middle-aged Teachers of Shenyang Pharmaceutical University(ZQN2018004).

摘　　要：Amicoumacin isocoumarin-type compounds are mainly derived from the secondary metabolites of Bacillus bacteria,and have potential biological activities such as antibacterial,anti-tumor,anti-inflammatory,and anti-ulcer.In our previous research,three amicoumacin-type isocoumarin compounds,Paenicoumacin A,Paenicoumacin B,and Paenicoumacin C(B and C are novel),were isolated from an endophytic bacterium in Houttuynia cordata.In this study,network pharmacology and bioinformatics techniques were used to analyze the potential activities of amicoumacin compounds in the treatment of liver cancer.These compounds were found to mainly regulate cellular oxidative stress,cancer process,nucleic acid metabolism,nutritional metabolism and other pathways.The findings provide useful information for subsequent experimental verification.

关 键 词：Houttuynia cordata PAENIBACILLUS ISOCOUMARIN liver cancer network pharmacology 

分 类 号：O62[理学—有机化学]