G蛋白偶联受体在运动调控动脉舒张过程中的机制  

Mechanism of G Protein-Coupled Receptors in Exercise Regulation of Arterial Diastole

作　　者：于凤至 孙朋[1,2] 刘淑卉 YU Fengzhi;SUN Peng;LIU Shuhui(Key Laboratory of Adolescent Health Assessment and Exercise Intervention of Ministry of Education,East China Normal University,Shanghai 200241,China;College of Physical Education and Health,East China Normal University,Shanghai 200241,China)

机构地区：[1]华东师范大学“青少年健康评价与运动干预”教育部重点实验室,上海200241 [2]华东师范大学体育与健康学院,上海200241

出　　处：《中国体育科技》2021年第10期79-88,共10页China Sport Science and Technology

基　　金：国家社会科学基金“十三五”规划教育学一般课题(BLA170225)。

摘　　要：动脉舒张功能障碍是诱发心血管疾病的重要因素。运动作为治疗心血管疾病的无创手段,可通过引起血流动力学和相关因子的变化,进一步调节动脉生理进程。通过综述以往研究发现,分布在动脉血管内皮细胞与血管平滑肌细胞上的G蛋白偶联受体在调节动脉舒张过程中发挥关键作用。运动可通过激活(或抑制)血管内皮细胞膜上相关G蛋白偶联受体,调控内皮源性血管因子的表达水平,进而调节血管平滑肌的舒张和收缩。同时,试图探讨“运动-GPCR-动脉舒张”的相关分子机制和信号通路。Arterial diastolic dysfunction is an important factor to induce cardiovascular disease.Exercise,as a noninvasive treatment for cardiovascular disease,can regulate the physiological process of arteries by causing changes in hemodynamics and related factors.This study reviews the findings of previous studies that G-protein coupled receptor,which are distributed in arterial vascular endothelial cells and vascular smooth muscle cells,play a key role in regulating arterial relaxation.Exercise can regulate the expression of endothelium-derived vascular factors by activating(or inhibiting).G protein-coupled receptors which on the vascular endothelial cell membrane,and thereby regulating the relaxation and contraction of vascular smooth muscle,and attempts to explore the molecular mechanisms and signaling pathways of“exercise-GPCR-arterial diastole”.

关 键 词：运动 G蛋白偶联受体PCR 内皮源性血管舒张因子 内皮源性血管收缩因子 动脉舒张 

分 类 号：G804.2[文化科学—运动人体科学]