围手术期过敏反应药物因素分析  

Drug Analysis in Perioperative Allergic Reaction

作　　者：王瑛琦 汪小海[1] 陈洁[1] 葛卫红[2] WANG Yingqi;WANG Xiaohai;CHEN Jie;GE Weihong(Department of Anesthesiology;Department of Pharmacy,Nanjing Drum Tower Hospital Affiliated to Medical College of Nanjing University,Nanjing 210008,China)

机构地区：[1]南京大学医学院附属鼓楼医院麻醉科,南京210008 [2]南京大学医学院附属鼓楼医院药学部,南京210008

出　　处：《医药导报》2021年第11期1500-1505,共6页Herald of Medicine

摘　　要：围手术期过敏反应可能发生在围手术期任何阶段,发病迅速,累及多个器官/系统,常危及患者生命。不同国家和地区导致围手术期过敏反应的主要药物不同,例如英国第六次国家调查发现英国导致围手术期过敏反应的药物按发生率依次为抗菌药物、肌松药、氯己定和专利蓝五号钙盐。我国最新专家共识认为,我国导致围手术期过敏反应的药物主要为肌松药、抗菌药物、胶体、脂类局部麻醉药、血液制品和鱼精蛋白。该文对国内外围手术期导致过敏反应的药物因素进行分析。Perioperative anaphylaxis may occur at many time during perioperative and may progress rapidly.It is a life-threatening event and often involves many systems.The main drugs caused anaphylaxis during perioperative period maybe differ from different regions.For example,the 6th National Audit Project in the UK has identified culprit agents included antibiotics,neuromuscular blocking agents,chlorhexidine and Patent Blue V.The latest Chinese expert consensus indicated that the causes of perioperative anaphylaxis included neuromuscular blocking agents,antibiotics,colloid,local anaesthetics,blood products and protamine.This article analyzes the drugs that cause allergic reactions during surgery both in China and abroad.

关 键 词：过敏反应 围手术期 致敏药物 

分 类 号：R969[医药卫生—药理学]