一氧化碳参与β-内酰胺化合物合成的研究进展  

Recent Advances on the Synthesis of β-Lactams by Involving Carbon Monoxide

作　　者：王鹏[1] 杨妲 刘欢 Wang Peng;Yang Da;Liu Huan(State Key Laboratory of Organometallic Chemistry,Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences,Shanghai 200032;Department of Chemistry,College of Science,China University of Petroleum(East China),Qingdao 266580)

机构地区：[1]中国科学院上海有机化学研究所金属有机化学国家重点实验室,上海200032 [2]中国石油大学(华东)理学院化学系,青岛266580

出　　处：《有机化学》2021年第9期3448-3458,共11页Chinese Journal of Organic Chemistry

基　　金：国家自然科学青年基金(No.21901250);中国博士后科学面上基金(No.2019M651625)资助项目.

摘　　要：β-内酰胺类化合物是具有高生物活性及高应用价值的抗生素,如何高效高选择性地设计、合成该类化合物一直是有机化学研究的热点问题.由于其环状结构中具有羰基结构,利用一氧化碳(CO)作为羰源与底物分子发生羰基化反应也发展成为合成β-内酰胺的有效方法.通过该方法可以一步高效合成结构多样性且新颖的β-内酰胺化合物.综述了近年来通过不同底物分子与CO发生羰基化反应构建β-内酰胺的研究进展,并且对该方法存在的问题以及未来发展方向进行了展望.β-Lactam compounds are antibiotics with high biological activity and high application value.Design and synthesis ofβ-lactams with high efficiency and high selectivity have always been a hot issue in organic chemistry.Because of the carbonyl group in the ring structure,the carbonylation reaction between substrate and carbon monoxide(CO)has also developed into a new method for synthesis ofβ-lactams,which can be used to synthesize novel and diverse structures in one step.In this paper,the carbonylation of different substrates with CO to synthesizeβ-lactams in recent years is reviewed,and the existing problems and future development of this strategy are prospected.

关 键 词：Β-内酰胺 一氧化碳 羰基化 氮杂环丙烷 烯酮 

分 类 号：TQ465[化学工程—制药化工] TQ236