2-氨基吡啶在构建五元、六元氮稠环合成中的应用  

Application of 2-Aminopyridines in the Synthesis of Five-and Six-Membered Azaheterocycles

作　　者：陈淇 陈思鸿 吴汉清 曾晓晴 陈伟清 孙国星 汪朝阳[1] Chen Qi;Chen Sihong;Wu Hanqing;Zeng Xiaoqing;Chen Weiqing;Sun Guoxing;Wang Zhaoyang(Key Laboratory of Theoretical Chemistry of Environment,Ministry of Education,Guangzhou Key Laboratory of Analytical Chemistry for Biomedicine,School of Chemistry,South China Normal University,Guangzhou 510006;Joint Key Laboratory of the Ministry of Education,Institute of Applied Physics and Materials Engineering,University of Macao,Macao 999078)

机构地区：[1]华南师范大学化学学院教育部环境理论化学重点实验室广州市生物医药分析化学重点实验室,广州510006 [2]澳门大学应用物理及材料工程研究院教育部联合重点实验室,澳门999078

出　　处：《有机化学》2021年第9期3482-3491,共10页Chinese Journal of Organic Chemistry

基　　金：广东省基础与应用基础研究基金(No.2021A1515012342);广东省科技计划(No.2017A010103016)资助项目.

摘　　要：2-氨基吡啶是一类重要的合成子,具有独特的双亲核结构,可与酮、醛、酸、多官能团酯类以及卤代芳烃等化合物反应,以构建五元、六元含氮稠杂环.近年来,基于2-氨基吡啶的成环反应倍受关注.鉴于此,以底物种类为分类依据,重点综述了近5年来基于2-氨基吡啶构建咪唑并[1,2-a]吡啶、吡啶并[1,2-a]嘧啶合成方法的研究进展,总结了其在有机合成方法学、药物合成和荧光探针等领域的应用,并展望了基于2-氨基吡啶的绿色化成环及其应用的未来发展趋势.2-Aminopyridine is a significant synthetic synthon,with unique dual nucleophilic structure.It can react with ketones,aldehydes,acids,multifunctional esters,halogenated aromatics and other compounds to synthesize five-and six-member azaheterocycles.In recent years,the cyclization reactions based on 2-aminopyridines have been under the spotlight.According to the different types of substrates,the research progress on the synthesis of imidazo[1,2-a]pyridines and pyrido[1,2-a]pyrimidines based on 2-aminopyridines in the past 5 years is reviewed,and its applications in organic synthesis methodology,drug synthesis and fluorescent probes are summarized.Furthermore,the development trend of green cyclization and its application based on 2-aminopyridines in the future are prospected.

关 键 词：2-氨基吡啶 咪唑并[1 2-a]吡啶 吡啶并[1 2-a]嘧啶 氮稠环化合物 C-N键构建 逆合成分析 

分 类 号：O626[理学—有机化学]