Selectfluor氧化合成2-芳基苯并噻唑的新方法  

A New Method for the Synthesis of 2-Arylbenzothiazoles Oxidized by Selectfluor

作　　者：傅琴姣 张瑞芹 裘浣沂 马仁超 马永敏 Fu Qinjiao;Zhang Ruiqin;Qiu Huanyi;Ma Renchao;Ma Yongmin(School of Pharmaceutical and Chemical Engineering,Taizhou University,Taizhou,Zhejiang 318000)

机构地区：[1]台州学院医药化工学院,浙江台州318000

出　　处：《有机化学》2021年第9期3585-3592,共8页Chinese Journal of Organic Chemistry

基　　金：浙江省领军型创新团队(No.2019R01005)资助项目.

摘　　要：开发了一种以芳基甲基酮或脂肪酮和2-氨基苯硫酚为原料,正丁醇为溶剂,120℃条件下经Selectfluor氧化合成2-取代苯并噻唑类衍生物的方法.通过改变底物芳基甲基酮上的取代基可以获得具有生物活性的药物中间体.2-Arylbenzothiazoles were effectively synthesized via an oxidative process by Selectfluor in 1-butanol at 120℃,using 2-arylbenzothiazoles and aryl/aliphatic ketones as starting materials.Bioactive pharmaceutical intermediates were obtained by selecting substituents on the ring of aryl methyl ketones.

关 键 词：选择性氟试剂 2-芳基苯并噻唑 芳基甲基酮 2-氨基苯硫酚 氧化 

分 类 号：O626.25[理学—有机化学] TQ460.1[理学—化学]