高价碘试剂参与酰胺的选择性二氟氯乙基化反应研究  

Study on the Selective Difluorochloroethylation Reactions of Amides with Hypervalent Iodine Reagent

作　　者：颜廷勋 陈超[2,3] 文丽荣[1] Yan Tingxun;Chen Chao;Wen Lirong(College of Chemistry and Molecular Engineering,Qingdao University of Science&Technology,Qingdao 266042;Key Laboratory of Bioorganic Phosphorus Chemistry&Chemical Biology,Ministry of Education,Department of Chemistry,Tsinghua University,Beijing 100084;State Key Laboratory of Elemental Organic Chemistry,Nankai University,Tianjin 300071)

机构地区：[1]青岛科技大学化工与分子工程学院,青岛266042 [2]清华大学化学系生命有机磷化学及化学生物学教育部重点实验室,北京100084 [3]南开大学元素有机化学国家重点实验室,天津300071

出　　处：《有机化学》2021年第9期3660-3667,共8页Chinese Journal of Organic Chemistry

基　　金：国家重点研发项目(No.2016YFB0401400);国家自然科学基金(Nos.22071129,21871158,21672120);霍英东教育基金(No.151014)资助项目.

摘　　要：含氟乙基化产物在生物医药和材料领域有着广泛的应用,合成含氟乙基的化合物有着重要意义.目前对三氟乙基化合物的合成有了相关报道,但是对于如何合成二氟乙基化产物却鲜有报道.通过氯二氟高价碘试剂和酰胺进行反应,选择性生成氮-氯二氟乙基化和氧-氯二氟乙基化产物,该反应的选择性通过溶剂选择即可调控,反应高效便捷实用.Fluoroethylation products have a wide range of applications in the fields of biomedicine and materials,and the synthesis of fluorine-containing ethyl compounds is very important.At present,there are related reports on the synthesis of trifluoroethyl compounds,but there are few reports on how to synthesize difluoroethylated products.In this paper,through the reaction of chlorodifluoro iodine reagent and amide,N-chlorodifluoroethylation and O-chlorodifluoroethylation products were selectively generated.The selectivity of the reaction can be controlled by the choice of solvent,and the reaction is efficient,convenient and practical.

关 键 词：氯二氟乙基高价碘 氟乙基化 二氟乙基化 三氟乙基化 

分 类 号：O621.25[理学—有机化学]