电化学氧化-碘促进丙酮α-H芳(烷)硒化制备α-芳(烷)硒基丙酮  

Electrochemical Oxidated-Iodide Promotedα-H Aryl(alkyl)selenation of Acetone for the Preparation ofα-Aryl(alkyl)selenoacetones

作　　者：易荣楠 刘冬娴[1] 吴啟林 赵明明[1] 王勇 王峥 Yi Rongnan;Liu Dongxian;Wu Qilin;Zhao Mingming;Wang Yong;Wang Zheng(Criminal Technology Department,Hunan Police Academy,Changsha 410138;Department of Forensic Science,School of Basic Medical Science,Central South University,Changsha 410013;Department of Chemistry,Hunan University of Science and Engineering,Yongzhou,Hunan 425100;Department of Chemistry and Chemical Engineering,Yangtze Normal University,Chongqing 408000)

机构地区：[1]湖南警察学院刑事科学技术系,长沙410138 [2]中南大学基础医学院法医学系,长沙410013 [3]湖南科技学院化学与生物工程学院,湖南永州425100 [4]长江师范学院化学化工学院,重庆408000

出　　处：《有机化学》2021年第9期3726-3732,共7页Chinese Journal of Organic Chemistry

基　　金：湖南省自然科学基金(Nos.2019JJ40392,2019JJ50193)资助项目.

摘　　要：α-芳(烷)硒基酮作为重要的中间体在有机合成方面具有重要的应用.报道了电化学氧化-碘促进下,丙酮α-H芳(烷)硒化制备α-芳(烷)硒基丙酮化合物的方法,本方法使用稳定、易得的二芳(烷)基二硒醚作为硒化试剂.与已有的其它方法相比,本方法具有反应条件温和、原子经济性高、底物适用范围广等优点,为α-芳(烷)硒基丙酮化合物的制备提供了一条绿色、高效的合成路径.α-Aryl(alkyl)selenyl ketones have been important intermediates in organic transformation.Here,a new route toα-aryl(alkyl)selenoacetones via the electrochemical oxidated iodide promotedα-H aryl(alkyl)selenation of acetone by using stable and easy available diaryl(alkyl)diselenides as selenide reagent is reported.Comparing to the previous methods,this strategy has the advantages of mild reaction conditions,high atom economy and wide functional groups tolerance,providing an efficient and green route toα-aryl(alkyl)selenoacetones.

关 键 词：有机电合成 碘促进反应 α-H芳(烷)硒化 α-芳(烷)硒基丙酮 

分 类 号：TQ266.1[化学工程—有机化工]