瞿麦的化学成分研究(Ⅰ)  

Chemical Constituents from the Stems and Leaves of Dianthus superbus(Ⅰ)

作　　者：洪玲洁 袁铭铭 李俊[1,2] 邹传生 周国平 HONG Ling-jie;YUAN Ming-ming;LI Jun;ZOU Chuan-sheng;ZHOU Guo-ping(Jiangxi University of Traditional Chinese Medicine,Nanchang 330004,China;Jiangxi Center for Drug Certification and Evalua-tion,Nanchang 330046,China;Jiangxi Institute for Drug Control,NMPA Key Laboratory of Quality Evaluation of Traditional Chinese Patent Medicine,Jiangxi Province Engineering Research Center of Drug and Medical Device Quality,Nanchang 330029,China)

机构地区：[1]江西中医药大学,江西南昌330004 [2]江西省药品认证审评中心,江西南昌330046 [3]江西省药品检验检测研究院,国家药品监督管理局中成药质量评价重点实验室,江西省药品与医疗器械质量工程技术研究中心,江西南昌330029

出　　处：《中药材》2020年第12期2933-2937,共5页Journal of Chinese Medicinal Materials

基　　金：江西省重点研发计划项目(20171BBG70104)。

摘　　要：目的:研究瞿麦的化学成分。方法:利用硅胶、Sephadex LH⁃20葡聚糖凝胶、ODS、MPLC等柱色谱方法进行化合物的分离纯化,根据化合物的理化性质、波谱方法进行结构鉴定。结果:从瞿麦醇提物的二氯甲烷部位中分离得到14个化合物,分别鉴定为:(+)⁃表松脂醇(1)、松脂醇(2)、邻苯二甲酸二丁酯(3)、(3Z,6Z,9Z)⁃3,6,9⁃nonadecatriene(4)、儿茶酚(5)、脱氢地芰普内酯(6)、金色酰胺醇酯(7)、皂皮酸(8)、去氢吐叶醇(9)、琥珀酸(10)、melrubiellin A(11)、melrubiellin B(12)、水杨酸(13)、青刺尖木脂醇(14)。结论:其中,化合物1~4、6~12、14为首次从瞿麦中分离得到。Objective:To study the chemical constituents from the stems and leaves of Dianthus superbus.Methods:The compounds were isolated and purified by silica gel,Sephadex LH⁃20,ODS,MPLC and other column chromatography methods.The structures were i⁃dentified by physicochemical properties and spectroscopic methods.Results:Fourteen compounds were isolated from dichloromethane ex⁃tract of ethanol extract of Dianthus superbus,and identified as(+)⁃epipinoresinol(1),pinoresinol(2),dibutyl phthalate(3),(3Z,6Z,9Z)⁃3,6,9⁃nonadecatriene(4),catechol(5),dehydrololiolide(6),aurantiamide acetate(7),quillaic acid(8),dehydrovomifoliol(9),succinic acid(10),melrubiellin A(11),melrubiellin B(12),salicylic acid(13),prinsepiol(14),respectively.Conclusion:Among them,compounds 1 to 4,6 to 12,14 are isolated from the stems and leaves of Dianthus superbus for the first time.

关 键 词：瞿麦 石竹科 化学成分 青刺尖木脂醇 

分 类 号：R284.1[医药卫生—中药学] R284.2[医药卫生—中医学]