小花鬼针草化学成分研究  

Chemical Constituents of Bidens parviflora

作　　者：李传厚 朱彦军 于绍华 蒋海强[1] 周洪雷[1] LI Chuan-hou;ZHU Yan-jun;YU Shao-hua;JIANG Hai-qiang;ZHOU Hong-lei(College of Pharmacy,Shandong University of Traditional Chinese Medicine,Jinan 250355,China;Shandong Medical College,Li-nyi 276000,China)

机构地区：[1]山东中医药大学药学院,山东济南250355 [2]山东医学高等专科学校,山东临沂276000

出　　处：《中药材》2020年第10期2419-2423,共5页Journal of Chinese Medicinal Materials

基　　金：山东省中医药科技发展计划(2019⁃0315);山东省重点研发计划(2017GSF19105)。

摘　　要：目的:研究小花鬼针草全草的化学成分。方法:对小花鬼针草70%乙醇提取物的乙酸乙酯部位和正丁醇部位采用正相硅胶、聚酰胺、ODS以及高效液相制备进行分离纯化,根据理化性质及波谱数据鉴定所得化合物的结构。结果:从小花鬼针草中分离得到19个化合物,分别鉴定为:原儿茶醛(1)、6,7⁃二羟基香豆素(2)、3⁃O⁃caf⁃feoyl⁃2⁃C⁃methyl⁃D⁃erythrono⁃1,4⁃lactone(3)、methyl⁃2⁃O⁃caffeoyl⁃2⁃C⁃methyl⁃D⁃erythronate(4)、(7S′,8S′)⁃sapiumin C(5)、7,3′,4′⁃三羟基黄酮(6)、原儿茶酸甲酯(7)、槲皮素⁃3,3′⁃二甲氧基⁃7⁃O⁃β⁃D⁃吡喃葡萄糖苷(8)、腺嘌呤(9)、肌苷(10)、异槲皮苷(11)、新绿原酸甲酯(12)、绿原酸甲酯(13)、5,3′⁃二羟基⁃3,6,4′⁃三甲氧基黄酮⁃7⁃O⁃β⁃D⁃吡喃葡萄糖苷(14)、4⁃O⁃咖啡酰基奎宁酸甲酯(15)、5⁃O⁃阿魏酰基奎宁酸(16)、奥卡宁⁃4′⁃O⁃β⁃D⁃吡喃葡萄糖苷(17)、8,3′,4′⁃三羟基黄酮⁃7⁃O⁃β⁃D⁃吡喃葡萄糖苷(18)、木犀草素⁃7⁃O⁃β⁃D⁃吡喃葡萄糖苷(19)。结论:其中,化合物5、6、9、10、12为首次从该属植物中分离得到,化合物1、4、8、14、16、18为首次从该植物中分离得到。Objective:To study the chemical constituents of the whole herb of Bidens parviflora.Methods:The ethyl acetate and n⁃butanol parts of 70%ethanol extract of Bidens parviflora were isolated and purified by silica,polyamide,ODS and HPLC,the structures of obtained compounds were identified by physicochemical properties and spectral data.Results:Nineteen compounds were isolated from Bidens parviflora and identified as protocatechuic aldehyde(1),6,7⁃dihydroxycoumarin(2),3⁃O⁃caffeoyl⁃2⁃C⁃methyl⁃D⁃erythrono⁃1,4⁃lactone(3),methyl⁃2⁃O⁃caffeoyl⁃2⁃C⁃methyl⁃D⁃erythronate(4),(7S′,8S′)⁃sapiumin C(5),7,3′,4′⁃trihydroxyflavone(6),protocate⁃chuic acid methyl ester(7),quercitrin⁃3,3′⁃dimethoxy⁃7⁃O⁃β⁃D⁃glucopyranoside(8),adenine(9),inosine(10),isoquercitrin(11),neochlorogenic acid methyl ester(12),chlorogenic acid methyl ester(13),5,3′⁃dihydroxy⁃3,6,4′⁃trimethoxyflavone⁃7⁃O⁃β⁃D⁃glucopyr⁃anoside(14),methyl 4⁃O⁃caffeoylquinate(15),5⁃O⁃feruloylquinic acid(16),okanin⁃4′⁃O⁃β⁃D⁃glucopyranoside(17),8,3′,4′⁃tri⁃hydroxyflavone⁃7⁃O⁃β⁃D⁃glucopyranoside(18),luteolin⁃7⁃O⁃β⁃D⁃glucopyranoside(19),respectively.Conclusion:Among them,compounds 5,6,9,10,12 are isolated from Bidens genus for the first time,compounds 1,4,8,14,16,18 are isolated from Bidens parviflora for the first time.

关 键 词：小花鬼针草 化学成分 腺嘌呤 肌苷 

分 类 号：R284.1[医药卫生—中药学] R284.2[医药卫生—中医学]