结核分枝杆菌PE/PPE蛋白家族生物学研究进展  

Research progress in the biology of PE/PPE protein family of Mycobacterium tuberculosis

作　　者：王璞 蔡玉荣 张刚[1,2] 孔云逸 穆爱娟 李勇 WANG Pu;CAI Yu-rong;ZHANG Gang;KONG Yun-yi;MU Ai-juan;LI Yong(Key Lab of Ministry of Education for Protection and Utilization of Special Biological Resources in Western,Yinchuan 750021,China;School of Life Science,Ningxia University,Yinchuan 750021,China;Agriculture and Rural Affairs Bureau of Helan County Agricultural Comprehensive Law Enforcement Brigade,Helan 750200,China)

机构地区：[1]宁夏大学西部生物资源保护与利用教育部重点实验室,银川750021 [2]宁夏大学生命科学学院,银川750021 [3]贺兰县农业农村局农业综合执法大队,贺兰750200

出　　处：《中国人兽共患病学报》2021年第10期937-944,共8页Chinese Journal of Zoonoses

基　　金：宁夏回族自治区重点研发计划项目资助课题(No.2017BN04);国家自然科学基金(No.31560694)。

摘　　要：结核分枝杆菌(Mycobacterium tuberculosis,MTB)是引起结核病的病原体,也是单一感染微生物导致死亡的最重要原因。在MTB基因组上有一类特殊的蛋白家族——PE/PPE蛋白家族,该蛋白家族对细菌毒力、抗原变异、宿主细胞命运等至关重要,且在特异性诊断试剂和疫苗研制中具有广阔的应用前景。本文将从PE/PPE蛋白家族的结构特征、生物学功能、及其对宿主免疫反应调控等方面的近年来研究进展作一综述。Mycobacterium tuberculosis(MTB)is the pathogen that causes tuberculosis,and it is also the most important cause of death from single microbial infection.There is a special protein family in the MTB genome-the PE/PPE protein family.This protein family is critical to bacterial virulence,antigenic variation,host cell fate,etc.,and has a broad application prospects in the development of specific diagnostic reagents and vaccines.In this paper,the structural characteristics,biological functions and the regulation of host immune response of PE/PPE protein family are reviewed.

关 键 词：结核分枝杆菌 PE/PPE TH1 巨噬细胞 

分 类 号：S855.2[农业科学—临床兽医学]