重金属镉致心血管疾病的潜在机制及治疗对策  

Potential mechanism and treatment of heavy metal cadmium-induced cardiovascular disease

作　　者：李沛轩 钟理[1,2] 郭蕊 LI PeiXuan;ZHONG Li;GUO Rui(Stem Cell and Biomedical Research Laboratory,School of Life Sciences,Hebei University,Baoding 071002,China;Institute of Life Science and Green Development,Hebei University,Baoding 071002,China)

机构地区：[1]河北大学生命科学学院干细胞与生物医学研究实验室,保定071002 [2]河北大学生命科学与绿色发展研究院,保定071002

出　　处：《中国科学：生命科学》2021年第9期1241-1253,共13页Scientia Sinica(Vitae)

基　　金：国家自然科学基金(批准号:31900534);河北省自然科学基金(批准号:C2019201349);河北省百人计划资助项目(批准号:E2019050010);河北大学高层次人才培养计划专项(批准号:801260201282)资助。

摘　　要：重金属是环境中常见的污染源,由于其结合能力强,对人体危害极大,成为环境污染物研究领域热点之一.心血管疾病是当今世界上发病率和致死率最高的疾病,严重影响着人类健康.长时间暴露于重金属环境下,发生心血管疾病的概率会显著增加.本文以重金属中对心脏影响最为明显的镉为代表,介绍了镉中毒导致的心血管疾病的相关机制,并对当下存在的可行性治疗对策进行了总结与展望.Heavy metals are common environmental pollutants.Owing to their strong binding ability,they are extremely harmful to the human body and have become a research topic garnering extensive interest in the study of environmental pollutants.Nowadays,cardiovascular diseases have the highest morbidity and mortality worldwide,which severely affect human health.Long-term exposure to heavy metal-containing environments greatly increases the incidence rate of cardiovascular diseases.This article aims to discuss the toxicity of cadmium,which exhibits the most obvious effect on the heart,and present the relevant mechanisms of cadmium poisoning-induced cardiovascular diseases.Current and future feasible treatment strategies have also been prospected and summarized.

关 键 词：心血管疾病 镉毒性 药物治疗 机制 

分 类 号：R54[医药卫生—心血管疾病] R114[医药卫生—内科学]