肝/脾CT值比、颈动脉斑块评分与冠状动脉粥样硬化程度关系的研究  

Study on the relationship of the ratio of liver/spleen CT value with carotid plaque score and the severity of coronary atherosclerosis

作　　者：石文达[1] 崔志新[1] 张丹[1] 李桂萍[1] 王国玉[2] 赵晓彬 肖旭[3] SHI Wen-da;CUI Zhi-xin;ZHANG Dan(Department of Radiology,Affiliated Hospital of Chengde Medical University,Chengde 067000,China;不详)

机构地区：[1]承德医学院附属医院放射科,河北承德067000 [2]承德医学院附属医院老年病科,河北承德067000 [3]承德医学院附属医院临床药学部,河北承德067000

出　　处：《中国医学装备》2021年第10期55-59,共5页China Medical Equipment

基　　金：承德市科技局科技支撑计划(201801A044)“肝/脾CT值比与动脉硬化斑块关系的研究”。

摘　　要：目的:探究肝/脾CT值比、颈动脉斑块评分与冠状动脉粥样硬化程度的关系。方法:选取医院收治的94例冠状动脉粥样硬化性心脏病(冠心病)患者纳入冠心病组,选择同期行CT冠状动脉血管造影(CTA)检查的30例非冠状动脉病变患者纳入对照组。两组患者均完成多排螺旋CT检查,测定肝脏CT值、肝/脾CT值比。依据冠状动脉血管造影Gensini评分,冠心病组94例患者中轻度狭窄35例,中度狭窄40例,重度狭窄19例,均行颈动脉斑块狭窄程度及斑块评估。分析两组肝脏CT值、肝/脾CT值比、颈动脉斑块评分评估冠状动脉粥样硬化程度的价值及三者之间的相关性。结果:冠心病组患者肝脏CT值、肝/脾CT值比低于对照组,皮下脂肪厚度、身体质量指数(BMI)高于对照组(t=-2.813,t=-2.049,t=2.219,t=2.494;P<0.05)。冠心病组轻度、中度和重度狭窄患者肝脏CT值、肝/脾CT值比、皮下脂肪厚度及BMI比较,差异有统计学意义(F=7.627,F=6.295,F=6.808,F=5.528;P<0.05);颈动脉狭窄积分、斑块积分及斑块数目比较,差异有统计学意义(F=35.726,F=19.574,F=90.609;P<0.05)。冠心病肝脏CT值、肝/脾CT值比与冠状动脉狭窄程度呈负相关(r=-0.315,r=-0.301;P<0.05),颈动脉狭窄积分、斑块积分及数目与冠状动脉狭窄程度呈正相关(r=0.697,r=0.664,r=0.576;P<0.05)。结论:肝脏CT值、肝/脾CT值比与冠状动脉病变程度呈负相关,颈动脉斑块狭窄程度、斑块积分及数目均与冠状动脉狭窄程度呈正相关,通过CT检查评估肝脏脂肪浸润、颈动脉斑块状况有助于指导冠状动脉病变程度评估。Objective:To investigate the relationship of the ratio of liver/spleen CT value with carotid plaque score and the severity of coronary atherosclerosis.Methods:94 patients with coronary atherosclerotic heart disease(coronary heart disease,CHD)who admitted to hospital were divided into CHD group.Meanwhile,30 patients without coronary artery lesions who underwent computed tomography angiography(CTA)were divided into control group.Both two groups of patients underwent multi-slice spiral CT examination for measuring the liver CT value and the ratio of liver/spleen CT value.According to Gensini score of coronary artery angiography,94 patients of CHD group were divided into mild stenosis group(n=35),moderate stenosis group(n=40)and severe stenosis group(n=19).All of them underwent the assessments of stenosis degree of carotid plaque and plaque.The values of the liver CT value,the ratio of liver/spleen CT values and carotid plaque score in evaluating the severity of coronary atherosclerosis were analyzed,and the correlations among the three aspects were also analyzed.Results:The liver CT value and the ratio of liver/spleen CT value of CHD group were significantly lower than those of control group,and the thickness of subcutaneous fat and body mass index(BMI)of CHD group were significantly higher than those of control group(t=-2.813,t=-2.049,t=2.219,t=2.494,P<0.05),respectively.There were statistically significant differences in above-mentioned indicators among the mild stenosis group,moderate stenosis group and severe stenosis group(F=7.627,F=6.295,F=6.808,F=5.528,P<0.05).The differences of carotid artery stenosis score,plaque score and the number of plaques among different stenosis groups also were statistically significant(F=35.726,F=19.574,F=90.609,P<0.05).Liver CT value and the ratio of liver/spleen CT value were negatively correlated with the severity of coronary artery stenosis(r=-0.315,r=-0.301,P<0.05),while carotid stenosis score,plaque score and the number of plaques were positively correlated with the severity

关 键 词：冠状动脉粥样硬化 CT血管造影(CTA) 多排螺旋CT 肝/脾CT值比 颈动脉斑块 肝脏CT 

分 类 号：R541.4[医药卫生—心血管疾病]