新疆喀什地区维吾尔族儿童先天性心脏病的危险因素分析  

Analysis on risk factors of congenital heart disease in Uygur children in Kashgar region of Xinjiang

作　　者：关丽娜[1] 许文娟[1] 李继军 古丽温切木[1] 尹东锋[1] 王瑞[1] 李悟[1] GUAN Li-Na;XU Wen-Juan;LI Ji-Jun(General Hospitdl of Xinjiang Military Command Urumqi,Xinjiang 830000,China)

机构地区：[1]新疆军区总医院,新疆乌鲁木齐830000 [2]喀什地区第二人民医院,新疆喀什844000

出　　处：《中国妇幼保健》2021年第20期4776-4779,共4页Maternal and Child Health Care of China

基　　金：新疆维吾尔自治区自然科学基金资助项目(2016D01C399)。

摘　　要：目的分析新疆喀什地区维吾尔族儿童先天性心脏病(CHD)的危险因素,为制定预防措施提供依据。方法选取喀什地区的212例CHD患儿为研究组,无CHD的286例维吾尔族儿童为对照组,采用单因素和多因素Logistic回归模型对CHD的危险因素进行分析。结果 212例CHD患儿病种检出前5位依次为室间隔缺损、房间隔缺损、动脉导管未闭、法洛氏四联症及心内膜垫缺损。多因素Logistic回归分析结果显示:母亲生育年龄≥35岁,CHD家族病史,既往流产史,母亲孕早期被动吸烟、饮酒、上呼吸道感染、用药及未补充叶酸是CHD的危险因素。结论环境和遗传因素在CHD的发生过程中均起重要作用,妊娠早期是胎儿心脏发育的关键阶段,加强育龄夫妇的健康教育和孕期保健,尽可能避免孕早期外界环境的不良影响十分重要。Objective To analyze the risk factors of congenital heart disease(CHD) in Uygur children in Kashgar region of Xinjiang, provide a basis for making preventive measures. Methods A total of 212 Uygur children with CHD were selected as case group, 286 Uygur children without CHD were selected as control group, univariate analysis and multivariate Logistic regression analysis were used to analyze the risk factors of CHD. Results The top five types of CHD among 212 children were ventricular septal defect(VSD), atrial septal defect(ASD), patent ductus arteriosus(PDA), tetralogy of Fallot, and endocardial cushion defect(ECD). Multivariate Logistic regression analysis showed that maternal reproductive age≥35 years old, CHD medical history, abortion history, passive smoking and drinking during the first trimester of pregnancy, upper respiratory tract infection, usage of medication, and without folic acid supplement were risk factors of CHD. Conclusion Both environmental and genetic factors play important roles in occurrence of CHD. The early stage of pregnancy is critical for fetal cardiac development. It is very important to strengthen health education and pregnancy health care for couples of childbearing age to avoid adverse effects of external environment in early pregnancy.

关 键 词：先天性心脏病 危险因素 维吾尔族 新疆喀什地区 

分 类 号：R715.5[医药卫生—妇产科学]