内蒙古自治区美沙酮维持治疗门诊服药依从性影响因素分析  

Influencing factors of drug compliance in methadone treatment clinic in Inner Mongolia Autonomous Region

作　　者：刘静 焦月英 杨虹 武玉梅 杨景元 LIU Jing;JIAO Yueying;YANG Hong;WU Yumei;YANG Jingyuan(Inner Mongolia integrated center for disease control and prevention,Hohhot 010031,China;Inner Mongolia People's Hospital,Hohhot 010031)

机构地区：[1]内蒙古自治区综合疾病预防控制中心,呼和浩特010031 [2]内蒙古自治区人民医院,呼和浩特010031

出　　处：《中国艾滋病性病》2021年第9期960-964,共5页Chinese Journal of Aids & STD

基　　金：内蒙古自治区卫生计生科研计划项目(201703076)。

摘　　要：目的评估内蒙古自治区社区美沙酮维持治疗门诊患者服药依从性,了解患者服药依从性的影响因素。方法采取随机抽样与整群抽样的方法对全区6个美沙酮维持治疗门诊进行回顾性调查,单因素分析比较维持组与脱失组人口学基本信息、家庭与社会支持情况、吸/戒毒经历等,多因素Logistic回归分析患者服药依从性的影响因素。结果调查门诊治疗患者613人,维持率为51.88%。年龄("40~54岁"与"25~39岁"相比较,OR=1.278,95%CI:0.747~2.186;"55~56岁"与"25~39岁"相比较,OR=4.047,95%CI:1.523~10.752)、居住状态(OR=5.015,95%CI:1.804~13.939)、是否为重复入组(OR=0.041,95%CI:0.021~0.077)、服药时间("1~6个月"与"<1个月"相比较,OR=2.108,95%CI:0.905~4.912;">6个月"与"<1个月"相比较,OR=8.022,95%CI:3.597~17.888)、往来门诊路上所花费的时间("30~60 min"与"<30 min"相比较,OR=0.406,95%CI:0.249~0.662;">60 min"与"<30 min"相比较,OR=0.162,95%CI:0.041~0.630)、近半年吸毒方式("单纯注射"与"单纯口吸或烫吸"相比较,OR=0.057,95%CI:0.009~0.365;"注射和其他方式混用"与"单纯口吸或烫吸"相比较,OR=0.108,95%CI:0.023~0.512)与美沙酮服药依从性相关(P<0.05)。结论内蒙古自治区美沙酮维持治疗门诊患者服药依从性差与年龄小、独居、重复入组、服药时间短、往来门诊路上花费的时间长、近半年注射吸毒和其他方式混用有关,因此应提高社区美沙酮维持治疗门诊的社会认知度,加强家庭的宣传教育。Objective To evaluate the compliance on drug use and its influencing factors of patients conducting methadone maintenance treatment(MMT) in the Inner Mongolia region.Methods Random sampling and cluster sampling methods were used for retrospective investigation in 6 MMT clinics.Univariate analysis was used to compare the basic demographic information,family & social support,and drug taken/rehabilitation experience between the maintenance and loss groups.Multivariate Logistic regression was used to analyze the influencing factors of patients’ medication compliance.Results 613 patients in MMT clinics were studied and the overfall maintenance rate was51.88%.According to multiple factors analysis,age(Compare "40-54 years old" with "25-39 years old",OR=1.278,95%CI:0.747-2.186."55-56 years old" compared with "25-39 years old",OR =4.047,95%CI:1.523-10.752"),living condition(OR=5.015,95%CI:1.804-13.939),repeat treatment accptance(OR =0.041,95%CI:0.021-0.077),histories of drug use(Compare 1 to 6 months with <1 month,OR =2.108,95%CI:0.905-4.912.Compare " >6 months" with " <1 month",OR =8.022,95%CI:3.597-17.888),time spend on travel between home and the clinic(Compare 30-60 minutes with <30 minutes,OR=0.406,95%CI:0.249-0.662." >60 min" is compared with " <30 min",OR=0.162,95%CI:0.041-0.630),drug-use in the past half-year and the way of using drugs("Pure injection" compared with "pure oral or scalding",OR =0.057,95%CI:0.009-0.365."Injection and other mixed use" compared with "oral or scalding alone",OR =0.108,95%CI:0.023-0.512) were the main influencing factor of patient treatment compliance in MMT clinic(P<0.05).Conclusion The poor compliance of methadone among the outpatients was related to factors as young age,living alone,repeated enrollment,short medication duration,long time spent on the way between the outpatient department and home,injecting or other mixed-use of drugs in the epat 6 months etc.,in Inner Mongolia region.Therefore,social awareness of community methadone maintenance treatment at the outpatient departme

关 键 词：美沙酮 依从性 影响因素 

分 类 号：R512.91[医药卫生—内科学]