抗氧化应激防治噪声性聋的研究进展  

Research progress on antioxidant therapy and prevention in noise-induced hearing loss

作　　者：顾晓娜[1] 戴艳红 佘万东[3] GU Xiaona;DAI Yanhong;SHE Wandong

机构地区：[1]南京中医药大学中西医结合鼓楼临床医学院,南京210008 [2]南京中医药大学附属中西医结合医院耳鼻咽喉科 [3]南京大学医学院附属鼓楼医院耳鼻咽喉头颈外科

出　　处：《临床耳鼻咽喉头颈外科杂志》2021年第9期850-853,共4页Journal of Clinical Otorhinolaryngology Head And Neck Surgery

基　　金：国家自然科学基金面上项目(No:81670931);江苏省第十四批“六大人才高峰”高层次人才项目-卫生行业(No:WSW-075);江苏省医学重点学科项目(No:ZDXKB2016015);南京市医学科技发展项目(No:ZKX17019)。

摘　　要：噪声性聋(noise-induced hearing loss,NIHL)是由于长期受噪声刺激而发生的一种缓慢的、进行性的听觉损伤。其听力曲线下降呈双侧感音神经性聋,常首先出现在3~6 kHz[1],长期暴露于噪声环境还可能损害学习能力与认知能力[2-3]。目前职业噪声问题已相当严重并亟待解决[4],但却缺乏有效的治疗手段。近30年来,NIHL的发病机制研究已非常深入,较为成熟的有机械性损伤、代谢性损害及血管性改变等.Noise-induced hearing loss usually refers to auditory impairment which is caused by long-term exposure to noise.The occupational noise problem is serious and urgently needs to be addressed,along with the lack of effective treatments.Recent studies have shown that the imbalance between oxidation and antioxidation is the source of the disease.To correct the redox reaction imbalance and to maintain an equilibrium of the redox reaction have always been the research focus of the prevention and treatment in noise induced hearing loss.This article reviews antioxidant therapy and prevention in noise induced hearing loss,including antioxidants,antioxidant enzymes and herbal medicine.

关 键 词：听觉丧失 噪声性 氧化应激 抗氧化剂 

分 类 号：R764.43[医药卫生—耳鼻咽喉科]