主要环境内分泌干扰物疾病负担的研究进展  

Research progress on disease burdens of major environmental endocrine disruptors

作　　者：王航 张李一 张蕴晖[1] WANG Hang;ZHANG Liyi;ZHANG Yunhui(School of Public Health/Key Laboratory of Public Health Safety of Ministry of Education,Fudan University,Shanghai 200032,China)

机构地区：[1]复旦大学公共卫生学院/公共卫生安全教育部重点实验室,上海200032

出　　处：《环境与职业医学》2021年第9期1033-1043,共11页Journal of Environmental and Occupational Medicine

基　　金：上海市第五轮公共卫生体系建设三年行动计划重点学科项目(GWV-10.1-XK08)。

摘　　要：全球范围内,环境因素导致的疾病负担较为沉重。欧盟和美国开展的相关研究中,主要研究物质为多溴联苯醚、有机磷酸酯类、邻苯二甲酸酯类、双酚A、滴滴涕、铅、镉、汞,关注的疾病为智力残疾、注意缺陷多动障碍、睾丸癌、隐睾症、不孕症、子宫内膜异位症、子宫肌瘤、低睾酮、儿童超重、成人肥胖、糖尿病、慢性肾病等。目前中国疾病负担研究评估的物质主要有邻苯二甲酸酯类、铅、镉、汞等,未来的研究可增加对多溴联苯醚、有机磷酸酯类、双酚A、滴滴涕所致疾病负担的关注,以完善中国环境内分泌干扰物相关的疾病负担评估。Globally, the burdens of disease attributable to environmental factors are high. The studies conducted in European Union and the United States mainly focus on environmental factors such as polybrominated diphenyl ethers(PBDEs), organophosphates(OPEs), phthalates(PAEs), bisphenol A(BPA), dichlorodiphenyltrichloroethane(DDT), lead, cadmium, and mercury, and health outcomes such as mental disabilities, attention deficit/hyperactivity disorder, testicular cancer, cryptorchidism, infertility, endometriosis, uterine fibroids, low testosterone, childhood overweight, adulthood obesity, diabetes, and chronic kidney disease. Currently, the burdens of disease attributable to PAEs, lead, cadmium, mercury have been assessed in studies in China. The roles of PBDEs, OPEs, BPA, and DDT in disease burden deserve more concern, aiming to improve the assessment of the burdens of disease associated with environmental endocrine disruptors in China.

关 键 词：环境内分泌干扰物 疾病负担 多溴联苯醚 有机磷酸酯类 邻苯二甲酸酯类 双酚A 

分 类 号：R12[医药卫生—环境卫生学]