microRNA参与男性生精过程的研究进展  

Research progress of microRNA involved in male spermatogenesis

作　　者：李晨曦 徐丽丹[1,2] Li Chenxi;Xu Lidan(Laboratory of Medical Genetics,Harbin Medical University,Harbin 150081,China;Key Laboratory of Preservation of Human Genetic Resources and Disease Control in China(Harbin Medical University),Ministry of Education,Harbin 150081,China)

机构地区：[1]哈尔滨医科大学医学遗传学研究室,150081 [2]中国遗传资源保护与疾病防控教育部重点实验室(哈尔滨医科大学),150081

出　　处：《国际遗传学杂志》2021年第4期261-267,共7页International Journal of Genetics

摘　　要：男性生精过程是一个多步骤、被精密调控的生理过程。单链非编码小RNA分子microRNA(简称miRNA)作为一种基因调控的重要方式,通过抑制和阻碍翻译过程来调节转录后基因沉默,参与各种生理过程。目前已有多项研究证实miRNA介导的转录后基因表达调控与男性精子发生过程存在密切相关性。因此,探讨miRNA在生精过程中的作用及其表达水平变化,有助于进一步了解男性生精的分子机制,寻找针对男性不育有效的生物标志物和治疗策略。本文将从miRNA直接参与或间接影响精子发生2个方面进行综述,总结miRNA在生精过程中的重要作用。Spermatogenesis is a multi-step and precisely regulated physiological process.As an important method of gene expression regulation,small single-stranded non-coding RNA molecules,microRNA(abbreviated miRNA),regulate post-transcriptional gene silencing(PTGS)by inhibiting the translation process,and participate in various physiological processes.At present,a number of studies have confirmed that miRNA-mediated post-transcriptional gene expression regulation is closely related to the male spermatogenesis.Therefore,exploring the role of miRNA in the process of spermatogenesis and their expressive changes during this process will help to further understand the molecular mechanism of spermatogenesis,and find effective biomarkers and treatment strategies of male infertility.This review focus on two aspects of miRNA that directly participate in or indirectly affect spermatogenesis and summarize the important role of miRNA in the process of spermatogenesis.

关 键 词：MIRNA 非编码RNA 精子发生 男性不育 生物标志物 

分 类 号：R339.21[医药卫生—人体生理学]