温敏性聚乳酸类材料的合成与应用进展  

Progress on the Preparation and Appliction of Thermosensitive Poly(lactic acid) Material

作　　者：肖颖 林建云 杨崇岭[2] 曹西颖 李晓微 吴若泓 罗时荷[1,3] 汪朝阳 XIAO Ying;LIN Jian-yun;YANG Chong-ling;CAO Xi-ying;LI Xiao-wei;WU Ruo-hong;LUO Shi-he;WANG Zhao-yang(School of Chemistry,South China Normal University,Guangzhou 510006,China;Guangdong Industry Polytechnic,Guangzhou 510300,China;Key Lab of Functional Molecular Engineering of Guangdong Province in SCUT,Guangzhou 510460,China)

机构地区：[1]华南师范大学化学学院,广州510006 [2]广东轻工职业技术学院,广州510300 [3]广东省功能分子工程重点实验室(华南理工大学),广州510460

出　　处：《高分子通报》2021年第10期31-43,共13页Polymer Bulletin

基　　金：国家自然科学基金项目(20772035);广东省科技计划项目(2017A010103016);广东省功能分子工程重点实验室资助课题(2017kf01);广州市科技计划项目(202002030362);广东省自然科学基金(2021A1515012342)。

摘　　要：温敏性材料能对温度的改变作出响应行为,是环境响应型材料中的研究热点。聚乳酸是一类生物相容性和可降解性良好的聚酯,在生物医用材料中应用广泛,但其亲水性不佳、主链中缺乏反应活性官能团等缺陷限制了其在药物控释等领域的深入应用。通过功能化改性,赋予聚乳酸温敏性,得到的温敏性聚乳酸类材料可兼有两类材料的优异性质。目前,温敏性聚乳酸类材料的制备,多基于开环聚合法,同时结合可逆加成-断裂链转移聚合、活性阳离子聚合、点击化学反应等合成策略。本文按照参与改性聚合物的不同进行分类,综述了近年来温敏性聚乳酸材料的合成与应用。展望未来,基于温敏性聚乳酸材料的多响应方向发展及相关材料制备方法的简化,将是研究的重要方向。Thermosensitive materials can respond to the change of temperature, which is a research focus of stimuli-responsive materials. As a kind of biodegradable polyester with good biocompatibility, poly(lacic acid)(PLA) is widely used in biomedical materials, but its poor hydrophilicity and lack of reactive functional groups in the main chain limit its further application in many areas such as drug control release. By means of functional modification, PLA can be endowed with thermosensitivity, and the obtained thermosensitive PLA-based material can have the excellent properties of both types of materials. At present, the preparation of thermosensitive PLA materials is mostly based on the ring-opening polymerization, combining with other synthesis strategies such as reversible addition-fragmentation chain transfer polymerization, living cationic polymerization and click chemistry. In this paper, the preparation and application of thermosensitive PLA materials in recent years are reviewed according to the classification of the polymers involved in the modification. Development of multi-responsive polymers based on thermosensitive PLA materials and the simplification of preparation methods of related materials will be important.

关 键 词：聚乳酸 温敏性 环境响应型材料 

分 类 号：TQ323.4[化学工程—合成树脂塑料工业]