黄连温胆汤加针刺治疗高海拔地区含顺铂方案化疗所致恶心呕吐的临床疗效观察  

Clinical efficacy observation of Huanglian Wendan Decoction and acupuncture on nausea and vomiting caused by chemotherapy with cisplatin-containing regimen in high altitude areas

作　　者：郑秋惠[1] 杨明珠 龚自坤 孙芳[1] 王淑萍[1] 王燕虎[1] 王法林[1] 李清梅[1] 贾小军[1] 鲍艳举[3] ZHENG Qiu-hui;YANG Ming-zhu;GONG Zi-kun;SUN Fang;WANG Shu-ping;WANG Yan-hu;WANG Fa-lin;LI Qing-mei;JIA Xiao-jun;BAO Yan-ju(Department of Hematology and Oncology,Qinghai Provincial Hospital of Traditional Chinese Medicine,Xining 810000,China;Qinghai University,Xining 810000,China;Guang'anmen Hospital,China Academy of Chinese Medical Sciences,Beijing 100053,China)

机构地区：[1]青海省中医院血液肿瘤科,西宁810000 [2]青海大学,西宁810000 [3]中国中医科学院广安门医院,北京100053

出　　处：《中华中医药杂志》2021年第9期5697-5700,共4页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：青海省科技厅应用基础研究(No.2019-ZJ-7089)。

摘　　要：目的:探讨黄连温胆汤加针刺治疗高海拔地区含顺铂方案化疗所致恶心呕吐(CINV)的临床疗效和安全性。方法:采用随机平行对照方法纳入使用含顺铂方案化疗的64例恶性肿瘤患者,对照组单纯给予西药止呕治疗,治疗组在此基础上加用黄连温胆汤+穴位针刺治疗。比较两组急性期及延迟期发生CINV的完全缓解率(CR)、完全控制率(CC)、至治疗失败的时间(TTF)、恶心与呕吐的严重程度及用药安全。结果:治疗组的全程、延迟期CC和延迟期CR显著优于对照组(P<0.05);延迟期的恶心、呕吐严重程度治疗组显著低于对照组(P<0.05)。结论:在常规西医止呕治疗基础上配合黄连温胆汤+穴位针刺,可提高全程CC、延迟期的CR和CC,并减轻延迟期发生CINV的严重程度。Objective: To explore the clinical efficacy and safety of Huanglian Wendan Decoction and acupuncture in high altitude areas for the treatment of nausea and vomiting caused by cisplatin-containing chemotherapy(CINV). Methods: A randomized parallel control method was used to enroll 64 cancer patients who received chemotherapy with a cisplatin-containing regimen. The control group was given western medicine for antiemetic treatment, and the treatment group was treated with Huanglian Wendan Decoction + acupuncture on this basis. The complete remission rate(CR), complete control rate(CC), time of treatment failure(TTF), the severity of nausea and vomiting, and medication safety of CINV in the acute and delayed phases were compared between the two groups. Results: CC in the whole and delayed phase, and CR in the delayed phase in the treatment group were significantly better than those in the control group(P<0.05). The severity of nausea and vomiting in the delayed phase was significantly lower in the treatment group than in the control group(P<0.05). Conclusion: On the basis of conventional Western medicine antiemetic treatment, combined with Huanglian Wendan Decoction + acupoint acupuncture, CC in the whole phase, CR and CC in the delayed phase can be significantly increased, and the severity of CINV in the acute and delayed phases can be reduced.

关 键 词：高海拔 化疗 恶心呕吐 中药 针刺 含顺铂方案 

分 类 号：R246.5[医药卫生—针灸推拿学]