聚酰胺用于选择性激光烧结3D打印截骨导板的性能研究  

Polyamide Properties Study for Selective Laser Sintering 3D Printed Cutting Guide

作　　者：项巍巍 黄野[2] 刘国彬[3] 柳剑[2] 张名俊 王卿 雷鹏坤 王郁琪 王小龙 万翔 Xiang Weiwei;Huang Ye;Liu Guobin(Johnson&Johnson(Suzhou)Medical Device,Suzhou 215126,China;Beijing Jishuitan Hospital,Beijing 100035,China;The First Hospital of Hebei Medical University,Shijiazhuang 050000,China)

机构地区：[1]强生(苏州)医疗器材有限公司,江苏苏州215126 [2]北京积水潭医院,北京100035 [3]河北医科大学第一医院,河北石家庄050000 [4]强生(上海)医疗器材有限公司,上海200030

出　　处：《实用骨科杂志》2021年第10期951-954,959,共5页Journal of Practical Orthopaedics

摘　　要：目的研究一种用于选择性激光烧结3D打印截骨导板的聚酰胺材料的机械、化学性能以及生物相容性。方法机械性能研究包括材料断裂延伸率、拉伸模量、抗拉强度、维卡软化温度、负荷变形温度和磨损质量。化学性能研究包括还原物质、酸碱度、重金属总量、蒸发残渣和紫外吸光度。生物学评价内容包括体外细胞毒性、皮肤致敏和皮内刺激。检测机械性能、化学性能以及生物相容性,并对其结果进行评价。结果机械性能:断裂延伸率为7.8%~22.3%,拉伸模量为1664~1982 MPa,抗拉强度为47.71~51.25 MPa,维卡软化温度为163.2~166.0℃,负荷变形温度为66.2~75.2℃,磨损质量为6.8~16.8 mg。化学性能符合GB19335-2003的要求。生物学评价:对体外细胞无潜在毒性影响,未发现皮肤致敏反应,未发现皮内刺激反应。结论该聚酰胺材料具有良好的机械、化学性能以及生物相容性,可用于生产制造手术3D打印截骨导板。Objective To study the mechanical,chemical properties and biological evaluation of a polyamide material used for selective laser sintering(SLS)3D printing of cutting guide.Methods Mechanical study included elongation at break,tensile modulus,tensile strength,vicat softening temperature,load deformation temperature and wearing.Chemical study included reducing substances,pH,heavy metals,evaporation residue and UV-absorption.Biological evaluation included vitro cytotoxicity test,skin sensitization test and intracutaneous reactivity test.The mechanical,chemical properties and biocompatibility were tested,and the results were evaluated.Results Mechanical Property:elongation at break 7.8%~22.3%,tensile modulus 1664~1982 MPa,tensile strength 47.71~51.25 MPa,vicat softening temperature 163.2~166.0℃,load deformation temperature 66.2~75.2℃,and wearing 6.8~16.8 mg.Chemical Property:complied with GB19335-2003.Biological Evaluation:no potential toxicity to vitro cells,no skin sensitization,and no intracutaneous reactivity.Conclusion The polyamide material has good mechanical,chemical properties and biocompatibility,which can be used to manufacture surgical 3D print cutting guide.

关 键 词：3D打印 聚酰胺 截骨导板 机械性能 化学性能 生物相容性 

分 类 号：R318.08[医药卫生—生物医学工程]