应重视人呼吸道合胞病毒感染的监测  

Attention should be paid to the detection and surveillance of human respiratory syncytial virus

作　　者：张燕[1] 宋金华[1] 许文波[1] Zhang Yan;Song Jinhua;Xu Wenbo(National Institute for Viral Diseases Control and Prevention,China CDC,NHC Key Laboratory of Medical Virology and Viral Diseases,WHO WPRO Regional Reference Measles/Rubella Laboratory,Beijing 102206,China)

机构地区：[1]国家卫生健康委员会医学病毒和病毒病重点实验室,中国疾病预防控制中心病毒病预防控制所,世界卫生组织西太平洋地区麻疹/风疹参比实验室,北京102206

出　　处：《中华医学杂志》2021年第36期2835-2838,共4页National Medical Journal of China

基　　金：国家科技重大专项(2018ZX10713002);国家自然科学基金(81772195)。

摘　　要：人呼吸道合胞病毒(HRSV)是婴幼儿发生严重下呼吸道感染的主要病原体,严重危害儿童健康。近年来HRSV疫苗和抗体类生物制品的研发已有较大突破,其研发及之后的使用策略均离不开HRSV流行和病毒变异特征的监测。世界卫生组织(WHO)高度重视HRSV流行及其变异特征的监测,但我国缺乏全国层面的、多中心的HRSV监测数据,各实验室所用的监测病例定义不一致,HRSV检测和监测方法不统一,不同实验室的结果难以进行比对分析。因此急需在我国建立全国层面多中心的HRSV监测网络,采用标准化的HRSV检测方法和监测方案进行HRSV流行特征和病毒变异特征的持续监测,为单克隆抗体和疫苗的研发、使用和评价提供基础科学数据。Human respiratory syncytial virus(HRSV)is the main pathogen of severe lower respiratory tract infection in infants and young children.It seriously endangers children′s health.In recent years,great breakthroughs have been made in the research and development of HRSV vaccines and antibody-based biological products.The research and development and use strategies are inseparable from the monitoring of HRSV prevalence and virus variation characteristics.The World Health Organization(WHO)pays great attentions to the surveillance of HRSV epidemiology and virus variation characteristics,but China lacks national level and multi-center HRSV surveillance data,the surveillance case definitions used by various laboratories are inconsistent,and the detection and surveillance methods of HRSV are not unified.Results from different laboratories are difficult to be compared and analyzed.Therefore,it is urgent to establish a nation-wide HRSV surveillance network in China,and to persistently monitor the epidemic characteristics and virus variation characteristics of HRSV by using standardized HRSV detection methods and surveillance guideline,so as to provide basic scientific data for the research and development,use and evaluation of monoclonal antibodies and vaccines.

关 键 词：人呼吸道合胞病毒 病毒监测 病毒变异 实验室网络 

分 类 号：R725.6[医药卫生—儿科] R181.3[医药卫生—临床医学]