Deficiency of mitochondrial aldehyde dehydrogenase increases type 2 diabetes risk in males via autophagy dysregulation  

作　　者：Xiang-Wei Liu Lin Jiang Peng Wang Xiao-Lei Sun Xin Ma Hong Zhu Zhen Dong Cheng Shen San-Li Qian Bing-Yu Li Zhen-Sheng Xu Ai-Jun Sun Jun-Bo Ge 

机构地区：[1]Shanghai Institute of Cardiovascular Diseases,Zhongshan Hospital,Fudan University,Shanghai 200032,China [2]Xiangya Hospital,Central South University,Changsha,Hunan 410008,China [3]Huashan Hospital,Fudan University,Shanghai 200040,China [4]Institute of Biomedical Science,Fudan University,Shanghai 200032,China

出　　处：《Chinese Medical Journal》2021年第18期2246-2248,共3页中华医学杂志（英文版）

基　　金：supported by grants from the National Natural Science Foundation of China(No.81700279);the National Science Fund for Distinguished Young Scholars(No.81725002).

摘　　要：Metrics To the editor:The diabetes epidemic has increasingly become a major public health concern worldwide.In 2014,there were 102.9 million diabetic adults in China,representing 24.4%of the world's diabetic population,even though China only comprised 18.7%of the global population at the time.[1]Furthermore,the estimated overall prevalence of diabetes and prediabetes was 10.9%and 35.7%,respectively,indicating China as one of the countries with the highest prevalence of diabetes in the world.[2]Although factors,including sedentary lifestyles and energy-dense diets,drive the diabetes epidemic,genetic architecture may also contribute to the susceptibility of an individual's response to environmental challenges.Aldehyde dehydrogenase(ALDH)2 is a key enzyme that eliminates toxic aldehydes by catalyzing their oxidation to non-reactive acids.Emerging evidence has suggested that individuals with ALDH2 deficiency have an increased risk of cardiovascular and metabolic diseases,in addition to alcohol intolerance,nitroglycerin tolerance,and carcinoma.[3]Notably,a unique ALDH2 loss-of-function allele,ALDH2∗2,is found in approximately 50%of the East Asian and 8%of the global populations.It has been reported that this ALDH2 mutation is associated with a higher prevalence of diabetes in coronary artery disease(CAD)patients,accompanied with increased C-reactive protein(CRP)levels.[4]ALDH2 mutation is also related to various diabetes risk factors,but the direct correlation remains elusive.Herein,we have explored the potential pathogenicity and mechanisms of ALDH2 deficiency in the development of type 2 diabetes in both laboratory and clinical settings.

关 键 词：DIABETES PREVALENCE eliminate 

分 类 号：R587.1[医药卫生—内分泌]